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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Barbarossa, Iole Tomassini Melis, Melania Mattes, Mitchell Z. Calò, Carla Muroni, Patrizia Crnjar, Roberto Tepper, Beverly J. |
| Description | Country affiliation: Italy Author Affiliation: Barbarossa IT ( Department of Biomedical Sciences, University of Cagliari, Monserrato, CA 09042, Italy.); Melis M ( Department of Biomedical Sciences, University of Cagliari, Monserrato, CA 09042, Italy); Mattes MZ ( Department of Food Science, School of Environmental and Biological Sciences, Rutgers University, New Brunswick, NJ 08901-8520, USA.); Calò C ( Department of Life and Environment Sciences, University of Cagliari, Monserrato, CA 09042, Italy.); Muroni P ( Department of Biomedical Sciences, University of Cagliari, Monserrato, CA 09042, Italy.); Crnjar R ( Department of Biomedical Sciences, University of Cagliari, Monserrato, CA 09042, Italy.); Tepper BJ ( Department of Food Science, School of Environmental and Biological Sciences, Rutgers University, New Brunswick, NJ 08901-8520, USA. Electronic address: tepper@aesop.rutgers.edu.) |
| Abstract | PROP responsiveness is associated with TAS2R38 haplotypes and fungiform papilla density. Recently, we showed that a polymorphism in the gene coding for the salivary trophic factor, gustin (CA6), affects PROP sensitivity by acting on cell growth and fungiform papillae maintenance, in a genetically homogeneous cohort. Since population homogeneity can lead to over estimation of gene effects, the primary aim of the present work was to confirm gustin's role in PROP bitterness intensity and fungiform papillae density in a genetically diverse population. Eighty subjects were genotyped for both genes by PCR techniques. PROP responsiveness was assessed by a filter paper method and fungiform papilla density was determined in each subject. As expected, PROP bitterness ratings were lower in individuals with the AVI/AVI diplotype of TAS2R38 than in individuals with PAV/PAV and PAV/AVI diplotypes. However, no differences in PROP bitterness among genotypes of the gustin gene, and no differences in the density of fungiform papillae related to TAS2R38 diplotype were found. In contrast, the density of fungiform papillae decreased as the number of minor (G) alleles at the gustin locus increased. In addition, the distribution of TAS2R38 genotypes within each gustin genotype group showed that the occurrence of recessive alleles at both loci was infrequent in the present sample compared to other populations. These findings confirm that papillae density is associated with gustin gene polymorphism, rs2274333 (A/G), in an ancestrally heterogeneous population, and suggest that variations in the frequency of allele combinations for these two genes could provide a salient explanation for discrepant findings for gustin gene effects across populations. |
| File Format | HTM / HTML |
| ISSN | 00319384 |
| Volume Number | 138 |
| e-ISSN | 1873507X |
| Journal | Physiology & Behavior |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-01-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Research Support, Non-u.s. Gov't Tongue Carbonic Anhydrases Anatomy & Histology Gene Frequency Humans Taste Perception Receptors, G-protein-coupled Administration & Dosage Propylthiouracil Genotyping Techniques Journal Article Young Adult Discipline Physiology Adolescent Genetics Adult Taste Polymorphism, Single Nucleotide Discipline Behavioral Neuroscience |
| Content Type | Text |
| Resource Type | Article |
| Subject | Experimental and Cognitive Psychology Behavioral Neuroscience |
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