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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Rojas-Durán, Fausto Pascual-Mathey, Luz I. Serrano, Karina Aranda-Abreu, Gonzalo E. Manzo, Jorge Soto-Cid, Abraham H. Hernandez, Ma Elena |
| Description | Country affiliation: Mexico Author Affiliation: Rojas-Durán F ( Centro de Investigaciones Cerebrales, Universidad Veracruzana, Xalapa, Ver., Mexico.); Pascual-Mathey LI ( Facultad de QFB, Universidad Veracruzana, Xalapa, Ver., Mexico.); Serrano K ( Doctorado en Investigaciones Cerebrales, Universidad Veracruzana, Xalapa, Ver., Mexico.); Aranda-Abreu GE ( Centro de Investigaciones Cerebrales, Universidad Veracruzana, Xalapa, Ver., Mexico.); Manzo J ( Centro de Investigaciones Cerebrales, Universidad Veracruzana, Xalapa, Ver., Mexico.); Soto-Cid AH ( Facultad de QFB, Universidad Veracruzana, Xalapa, Ver., Mexico.); Hernandez ME ( Centro de Investigaciones Cerebrales, Universidad Veracruzana, Xalapa, Ver., Mexico. Electronic address: elenahernandez@uv.mx.) |
| Abstract | Prolactin (PRL) is a key hormone for prostate function, with a basal level in serum and associated with two characteristic circadian peaks. In the male rat, the execution of one bout of sexual behavior with consecutive ejaculations produces a significant transient increase in PRL. However, the impact of a constant sexual life on both PRL levels and prostate function is unknown. Thus, by using constantly copulating males we analyzed the levels of serum PRL, the effect on prostate PRL receptors, and activation of pStat3, pStat5 and Mapk signaling pathways. Sexually experienced Wistar male rats were used, which underwent periodic sessions of sexual behavior tests. Males were subjected to a session of sexual behavior to achieve at least one and up to four ejaculations. Of these, a blood sample was collected from randomly selected males and the ventral prostate was removed for analysis. Serum PRL was quantified, the mRNA for PRL receptors was determined, and signaling pathways were analyzed. Data show that a constant sexual life produced a constant elevation of PRL in serum during four consecutive ejaculations. The ventral prostate showed a different mRNA expression profile for the long and short isoform of the PRL receptor, and both mRNA levels increased. Although the gland did not show modification of the activation of the pStat5 signaling pathway, the levels of pStat3 increased, and the Mapk pathway showed one significant elevation after the third ejaculation. Thus, we showed that an active and constant sexual life produces a sustained increase in serum PRL, its receptors, and the pStat3 signaling pathway. These responses seem to underlie the required physiological need to produce the quantity and quality of prostatic semen to ensure the appropriate environment for sperm to reach and fertilize the ovum. |
| File Format | HTM / HTML |
| ISSN | 00319384 |
| Volume Number | 138 |
| e-ISSN | 1873507X |
| Journal | Physiology & Behavior |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-01-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Copulation Research Support, Non-u.s. Gov't Stat5 Transcription Factor Rats, Wistar Rna, Messenger Male Random Allocation Metabolism Stat3 Transcription Factor Blood Blotting, Western Journal Article Discipline Physiology Animals Prolactin Ejaculation Protein Isoforms Polymerase Chain Reaction Physiology Map Kinase Signaling System Receptors, Prolactin Prostate Discipline Behavioral Neuroscience |
| Content Type | Text |
| Resource Type | Article |
| Subject | Experimental and Cognitive Psychology Behavioral Neuroscience |
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