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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Hussain, Rifat J. Jacobson, Lauren |
| Description | Country affiliation: United States Author Affiliation: Hussain RJ ( Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, NY 12208, USA.); Jacobson L ( Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, NY 12208, USA. Electronic address: jacobsL@mail.amc.edu.) |
| Abstract | Our laboratory has previously shown that antidepressants regulate glucocorticoid receptor (GR) expression in the prefrontal cortex (PFC). To determine if PFC GR are involved in antidepressant effects on behavior or hypothalamic-pituitary-adrenocortical (HPA) axis activity, we treated floxed GR male mice with saline or 15 or 30 mg/kg/d imipramine after PFC injection of adeno-associated virus 2/9 vectors transducing expression of Cre recombinase, to knock-down GR (PFC-GRKD), or green fluorescent protein (PFC-GFP), to serve as a control. The pattern of virally transduced GR deletion, common to all imipramine treatment groups, included the infralimbic, prelimbic, and medial anterior cingulate cortex at its largest extent, but was confined to the prelimbic and anterior cingulate cortex at its smallest extent. PFC GR knock-down increased behavioral sensitivity to imipramine, with imipramine-treated PFC-GRKD but not PFC-GFP mice exhibiting significant decreases in depression-like immobility during forced swim. PFC GR deletion did not alter general locomotor activity. The 30 mg/kg dose of imipramine increased plasma corticosterone levels immediately after a 5-min forced swim, but PFC GR knock-down had no significant effect on plasma corticosterone under these experimental conditions. We conclude that PFC GR knock-down, likely limited to the medial prelimbic and anterior cingulate cortices, can increase behavioral sensitivity to antidepressants. These findings indicate a novel role for PFC GR in influencing antidepressant response. |
| File Format | HTM / HTML |
| ISSN | 00319384 |
| e-ISSN | 1873507X |
| DOI | 10.1016/j.physbeh.2014.10.019 |
| Journal | Physiology & Behavior |
| Volume Number | 138 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-01-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Immunohistochemistry Research Support, N.i.h., Extramural Corticosterone Hypothalamo-hypophyseal System Antidepressive Agents Motor Activity Blood Gene Knockdown Techniques Discipline Physiology Imipramine Disease Models, Animal Deficiency Mice, Inbred C57bl Drug Therapy Receptors, Glucocorticoid Mice, Transgenic Pharmacology Depressive Disorder Drug Effects Prefrontal Cortex Physiopathology Animals Stress, Psychological Pituitary-adrenal System Discipline Behavioral Neuroscience |
| Content Type | Text |
| Resource Type | Article |
| Subject | Experimental and Cognitive Psychology Behavioral Neuroscience |
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