NDLI: Intranasal dexmedetomidine premedication reduces minimum alveolar concentration of sevoflurane for laryngeal mask airway insertion and emergence delirium in children: a prospective, randomized, double-blind, placebo-controlled trial.

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Intranasal dexmedetomidine premedication reduces minimum alveolar concentration of sevoflurane for laryngeal mask airway insertion and emergence delirium in children: a prospective, randomized, double-blind, placebo-controlled trial.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Yao, Yusheng Qian, Bin Lin, Ying Wu, Weilan Ye, Huazhen Chen, Yanqing
Description	Country affiliation: China Author Affiliation: Yao Y ( Department of Anesthesiology, Fujian Provincial Hospital, Provincial Clinical College of Fujian Medical University, Fuzhou, China.)
Abstract	BACKGROUND: We conducted a prospective, randomized, double-blind, placebo-controlled study to verify the hypothesis that intranasal dexmedetomidine premedication can reduce the minimum alveolar concentration of sevoflurane for laryngeal mask airway insertion in children. METHODS: Ninety American Society of Anesthesiologists (ASA) physical status I subjects, aged 3-7 years, were randomized to three equal groups to receive saline (Group S), dexmedetomidine 1 µg · kg(-1) (Group D1 ), or dexmedetomidine 2 µg · kg(-1) (Group D2 ) approximately 45 min before anesthesia. The minimum alveolar concentration for laryngeal mask airway insertion of sevoflurane was determined according to the Dixon's up-and-down method. Emergence delirium was evaluated using the Pediatric Anesthesia Emergence Delirium (PAED) scale in the postanesthesia care unit (PACU). RESULTS: Dexmedetomidine premedication of 1 and 2 µg · kg(-1) was associated with reduction in sevoflurane from 1.92% to 1.53% and 1.23%, corresponding to decrease of 20% and 36%, respectively. The peak PAED scores (median [IQR]) were 9 [8-11.5], 5 [3-5.3], and 3 [2-4] in Group S, Group D1, and Group D2 , respectively. The incidence of emergence delirium (defined as peak PAED score ≥ 10) was significantly lower in Groups D1 and D2 than in Group S (P < 0.001). Simultaneously, the induction qualities and the parent's satisfaction scores were significantly higher in Groups D1 and D2 than in Group S (P < 0.001). CONCLUSION: Intranasal dexmedetomidine premedication produces a dose-dependent decrease in the minimum alveolar concentration for laryngeal mask airway insertion of sevoflurane and emergence delirium in the PACU.
File Format	HTM / HTML
ISSN	11555645
Issue Number	5
Volume Number	25
e-ISSN	14609592
Journal	Pediatric Anesthesia
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2015-05-01
Publisher Place	France
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Delirium Research Support, Non-u.s. Gov't Prospective Studies Humans Child, Preschool Double-blind Method Male Journal Article Female Hypnotics And Sedatives Child Anesthetics, Inhalation Prevention & Control Laryngeal Masks Methyl Ethers Treatment Outcome Pharmacology Administration & Dosage Randomized Controlled Trial Administration, Intranasal Drug Synergism Dexmedetomidine Anesthesia Recovery Period Discipline Anesthetics Pharmacokinetics Methods Premedication
Content Type	Text
Resource Type	Article
Subject	Anesthesiology and Pain Medicine Pediatrics, Perinatology and Child Health

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