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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Mizrak, Ayse Ganidagli, Suleyman Cengiz, Mehri T. Oner, Unsal Saricicek, Vahap |
| Description | Country affiliation: Turkey Author Affiliation: Mizrak A ( Department of Anesthesiology and Reanimation, Gaziantep University Medical Faculty, School of Medicine, Gaziantep University, 27310 Sahinbey, Gaziantep, Turkey. aysemizrak@mynet.com) |
| Abstract | We investigated the effect of intravenous premedication with single dose of dexmedetomidine (DEX) on volatile anesthetic induction time and sevoflurane requirements of anesthesia maintenance in adults by monitoring the bispectral index (BIS). Sixty adult patients with status of ASA I–II undergoing general anesthesia with endotracheal intubation were randomly divided into two groups: The first group; a control group (group C, n = 30) and the second group; DEX group (group D, n = 30). Each patient in group D was premedicated with intravenous DEX 0.5 μg/kg or placebo 10 min before the induction of anesthesia. Anesthesia was induced by fentanyl 1 μg/kg, 1:1 ratio of nitrous oxide and oxygen and sevoflurane of 5–8 % and rocuronium bromur (Esmeron) 0.5 mg/kg keeping BIS values at 40–50. Time to induction of anesthesia, BIS, End-tidal sevoflurane concentration $(Et_{sevoflurane}),$ End-tidal $CO_{2}$ concentration, duration of surgery, recovery time, hemodynamic variables, adverse effects were recorded intraoperatively. Analgesic requirement was noted in postoperative 24 h-period. The time to induction of anesthesia (p < 0.0001) and $Et_{sevoflurane}$ at 1 min (p < 0.05) were significantly lower in group D than in group C. Intravenous premedication with 0.5 μg/kg of DEX decreased the induction time by almost 75 % and provided a significant decrease in $Et_{sevoflurane}.$ |
| File Format | HTM / HTML |
| ISSN | 13871307 |
| Issue Number | 3 |
| Volume Number | 27 |
| e-ISSN | 15732614 |
| Journal | Journal of Clinical Monitoring and Computing |
| Language | English |
| Publisher | Springer |
| Publisher Date | 2013-06-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Medical Informatics Anesthesia, Inhalation Methods Dexmedetomidine Administration & Dosage Methyl Ethers Premedication Adrenergic Alpha-2 Receptor Agonists Adult Anesthetics, Inhalation Consciousness Monitors Double-blind Method Female Humans Hypnotics And Sedatives Male Middle Aged Monitoring, Intraoperative Journal Article Randomized Controlled Trial |
| Content Type | Text |
| Resource Type | Article |
| Subject | Anesthesiology and Pain Medicine Critical Care and Intensive Care Medicine Health Informatics |
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