NDLI: Comparison of buccal and nasal dexmedetomidine premedication for pediatric patients.

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Comparison of buccal and nasal dexmedetomidine premedication for pediatric patients.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Cimen, Z. Serhan Hanci, Ayse Sivrikaya, G. Ulufer Kilinc, Leyla T. Erol, Melahat K.
Description	Country affiliation: Turkey Author Affiliation: Cimen ZS ( Department of 2nd Anesthesiology and Reanimation, Sisli Etfal Training and Research Hospital, Istanbul, Turkey.)
Abstract	BACKGROUND: Alpha-2 adrenergic agonists are used to premedicate pediatric patients to reduce separation anxiety and achieve calm induction. The clinical effects of clonidine are similar whether via the oral or nasal route. However, oral dexmedetomidine is not preferred because of its poor bioavailability. The objective of this study was to evaluate the effects of nasal versus buccal dexmedetomidine used for premedication in children. METHODS: Sixty-two patients, aged 2-6 years, undergoing minor elective surgery were randomly assigned to two groups to receive dexmedetomidine, either 1 µg·kg(-1) buccally (group B) or 1 µg·kg(-1) intranasally (group N) for premedication 45 min before the induction of anesthesia. Heart rate, peripheral oxygen saturation, and respiratory rate were measured before and every 10 min after administering dexmedetomidine in all children. Level of sedation was assessed every 10 min until transport to operating room. Drug acceptance, parental separation, and face mask acceptance scores were recorded. RESULTS: There was no significant difference between the two groups in patient characteristics, nor was there any significant difference between the two groups in heart rate, respiratory rate, or SpO(2) values at all times after premedication. Levels of sedation, parental separation, and mask acceptance scores were significantly higher in group N than in group B at the various times. CONCLUSIONS: These results suggest that intranasal administration of 1 µg·kg(-1) dexmedetomidine is more effective than buccal administration of 1 µg·kg(-1) dexmedetomidine for premedication in children.
File Format	HTM / HTML
ISSN	11555645
Issue Number	2
Volume Number	23
e-ISSN	14609592
Journal	Pediatric Anesthesia
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2013-02-01
Publisher Place	France
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Prospective Studies Comparative Study Psychology Humans Child, Preschool Double-blind Method Male Preanesthetic Medication Administration, Buccal Blood Journal Article Child Behavior Endpoint Determination Hypnotics And Sedatives Female Child Anesthesia, Inhalation Oxygen Adverse Effects Administration & Dosage Pharmacology Randomized Controlled Trial Administration, Intranasal Drug Effects Anxiety, Separation Dexmedetomidine Discipline Anesthetics Hemodynamics Respiratory Mechanics Methods
Content Type	Text
Resource Type	Article
Subject	Anesthesiology and Pain Medicine Pediatrics, Perinatology and Child Health

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