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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Yao, Yusheng Qian, Bin Chen, Yanqing Zhou, Lijuan Liu, Jin |
| Description | Country affiliation: China Author Affiliation: Yao Y ( Department of Anesthesiology and Translational Neuroscience Center, West China Hospital, Sichuan University, Chengdu 610041, China); Qian B ( Department of Anesthesiology, The People's Hospital of Fujian Province, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China.); Chen Y ( Department of Anesthesiology, Fujian Provincial Hospital, Fujian Provincial Clinical Medical College, Fujian Medical University, Fuzhou 350001, China.); Zhou L ( Department of Anesthesiology, Fujian Provincial Hospital, Fujian Provincial Clinical Medical College, Fujian Medical University, Fuzhou 350001, China.); Liu J ( Department of Anesthesiology and Translational Neuroscience Center, West China Hospital, Sichuan University, Chengdu 610041, China. Electronic address: sculiujin@126.com.) |
| Abstract | STUDY OBJECTIVE: To determine the effects of dexmedetomidine premedication on the minimum alveolar concentration of sevoflurane for tracheal intubation (MACTI) in children. DESIGN: Prospective, randomized, clinical comparison study. SETTING: Operating room of an academic hospital. PATIENTS: 90 pediatric, ASA physical status 1 patients, aged 3 to 7 years, scheduled for minor elective surgery. INTERVENTIONS: Patients were randomized to three groups to receive placebo, dexmedetomidine 1 µg/kg, or dexmedetomidine 2 µg/kg approximately 60 minutes before anesthesia. Anesthesia was induced with sevoflurane. Each concentration of sevoflurane for which a tracheal intubation was attempted was predetermined according to modification of the Dixon's up-and-down method, with 0.25% as a step size and held constant for at least 15 minutes before tracheal intubation. All responses ('movement' or 'no movement') to tracheal intubation were assessed. MEASUREMENTS AND MAIN RESULTS: The MACTI of sevoflurane was 2.82% ± 0.17% in the control group, 2.26% ± 0.18% in the 1 µg/kg dexmedetomidine group, and 1.83% ± 0.16% in the 2 µg/kg dexmedetomidine group. Dexmedetomidine premedication (1 and 2 µg/kg) decreased the MACTI of sevoflurane by 20% and 35%, respectively. There were no clinically significant episodes of hypotension or bradycardia in any patients. CONCLUSION: Intranasal dexmedetomidine premedication produces a dose-dependent decrease in the concentration of sevoflurane needed for tracheal intubation in children. |
| File Format | HTM / HTML |
| ISSN | 09528180 |
| Issue Number | 4 |
| Volume Number | 26 |
| e-ISSN | 18734529 |
| Journal | Journal of Clinical Anesthesia |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2014-06-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Anesthesiology Dexmedetomidine Pharmacology Hypnotics And Sedatives Methyl Ethers Pharmacokinetics Pulmonary Alveoli Metabolism Administration, Intranasal Anesthetics, Inhalation Administration & Dosage Child Child, Preschool Dose-response Relationship, Drug Double-blind Method Elective Surgical Procedures Methods Female Humans Intubation, Intratracheal Male Premedication Prospective Studies Comparative Study Journal Article Randomized Controlled Trial Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Anesthesiology and Pain Medicine |
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