NDLI: Radiation microbeams as spatial and temporal probes of subcellular and tissue response.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Schettino, Giuseppe Al Rashid, Shahnaz T. Prise, Kevin M.
Description	Country affiliation: United kingdom Author Affiliation: Schettino G ( Centre for Cancer Research & Cell Biology, Queen's University Belfast, 97 Lisburn Road, Belfast BT97BL, UK.)
Abstract	Understanding the effects of ionizing radiations are key to determining their optimal use in therapy and assessing risks from exposure. The development of microbeams where radiations can be delivered in a highly temporal and spatially constrained manner has been a major advance. Several different types of radiation microbeams have been developed using X-rays, charged particles and electrons. For charged particles, beams can be targeted with sub-micron accuracy into biological samples and the lowest possible dose of a single particle track can be delivered with high reproducibility. Microbeams have provided powerful tools for understanding the kinetics of DNA damage and formation under conditions of physiological relevance and have significant advantages over other approaches for producing localized DNA damage, such as variable wavelength laser beam approaches. Recent studies have extended their use to probing for radiosensitive sites outside the cell nucleus, and testing for mechanisms underpinning bystander responses where irradiated and non-irradiated cells communicate with each other. Ongoing developments include the ability to locally target regions of 3D tissue models and ultimately to target localized regions in vivo. With future advances in radiation delivery and imaging microbeams will continue to be applied in a range of biological studies.
File Format	HTM / HTML
ISSN	13835718
e-ISSN	18793592
DOI	10.1016/j.mrrev.2010.01.005
Journal	Mutation Research/Genetic Toxicology and Environmental Mutagenesis
Issue Number	1-3
Volume Number	704
Language	English
Publisher	Elsevier
Publisher Date	2010-04-01
Publisher Place	Netherlands
Access Restriction	Open
Subject Keyword	Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Dna Repair Discipline Genetics Radiation X-rays Discipline Biochemistry Bystander Effect Radiation Dosage Dna Damage Technology, Radiologic Cell Culture Techniques Electrons Radiation, Ionizing
Content Type	Text
Resource Type	Article
Subject	Genetics Health, Toxicology and Mutagenesis

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