NDLI: Spatiotemporal investigations of DNA damage repair using microbeams.

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Spatiotemporal investigations of DNA damage repair using microbeams.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Schettino, G. Ghita, M. Richard, D. J. Prise, K. M.
Description	Country affiliation: United kingdom Author Affiliation: Schettino G ( CCRCB, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7BL, UK. g.schettino@qub.ac.uk)
Abstract	Cellular response to radiation damage is made by a complex network of pathways and feedback loops whose spatiotemporal organisation is still unclear despite its decisive role in determining the fate of the damaged cell. Revealing the dynamic sequence of the repair proteins is therefore critical in understanding how the DNA repair mechanisms work. There are also still open questions regarding the possible movement of damaged chromatin domains and its role as trigger for lesion recognition and signalling in the DNA repair context. The single-cell approach and the high spatial resolution offered by microbeams provide the perfect tool to study and quantify the dynamic processes associated with the induction and repair of DNA damage. We have followed the development of radiation-induced foci for three DNA damage markers (i.e. Î³-H2AX, 53BP1 and hSSB1) using normal fibroblasts (AG01522), human breast adenocarcinoma cells (MCF7) and human fibrosarcoma cells (HT1080) stably transfected with yellow fluorescent protein fusion proteins following irradiation with the QUB X-ray microbeam (carbon X-rays <2 µm spot). The size and intensity of the foci has been analysed as a function of dose and time post-irradiation to investigate the dynamics of the above-mentioned DNA repair processes and monitor the remodelling of chromatin structure that the cell undergoes to deal with DNA damage.
File Format	HTM / HTML
ISSN	01448420
Issue Number	2-4
Volume Number	143
e-ISSN	17423406
Journal	Radiation Protection Dosimetry
Language	English
Publisher	Oxford University Press
Publisher Date	2011-02-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Research Support, Non-u.s. Gov't Dna Repair Humans Instrumentation Radiation Dosage Discipline Radiobiology Dna Damage Journal Article Chemistry Radiobiology Dna Radiation Effects Genetics Physiology Cell Culture Techniques
Content Type	Text
Resource Type	Article
Subject	Radiology, Nuclear Medicine and Imaging Public Health, Environmental and Occupational Health Radiological and Ultrasound Technology Radiation

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