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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Malka, Victor Faure, Jérôme Gauduel, Yann A. |
| Description | Country affiliation: France Author Affiliation: Malka V ( Laboratoire d'Optique Appliquée-CNRS UMR 7639, Ecole Nationale Supérieure des Techniques Avancées, Ecole Polytechnique, 91761 Palaiseau, France. victor.malka@ensta.fr) |
| Abstract | Deeply understanding the basic mechanisms of radiation damage in vitro and on living cells, starting from the early radical and molecular processes to mutagenic DNA lesions, cell signalling, genomic instability, apoptosis, microenvironment and Bystander effects, radio sensitivity should have many practical consequences such as the customization of cancer radiotherapy or radioprotection protocols. In this context, innovative laser-plasma accelerators provide ultra-short particle beams (electrons, protons) with parameters of interest for radiation biology and medical physics. This review article approaches some complex links that exist between radiation physics of new pulsed irradiation sources and potential biomedical applications. These links concern mainly the understanding of spatio-temporal events triggered by a radiation, within a fluctuating lapse of time from the initial energy deposition to primary damages of biological interest. |
| File Format | HTM / HTML |
| ISSN | 13835718 |
| e-ISSN | 18793592 |
| Journal | Mutation Research/Genetic Toxicology and Environmental Mutagenesis |
| Issue Number | 1-3 |
| Volume Number | 704 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2010-04-01 |
| Publisher Place | Netherlands |
| Access Restriction | Open |
| Subject Keyword | Research Support, Non-u.s. Gov't Discipline Genetics Health Physics Discipline Biochemistry Radiotherapy Dna Damage Neoplasms Radiobiology Technology, Radiologic Electrons |
| Content Type | Text |
| Resource Type | Article |
| Subject | Genetics Health, Toxicology and Mutagenesis |
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