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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Dutreix, M. Cosset, J. M. Sun, J-S |
| Description | Country affiliation: France Author Affiliation: Dutreix M ( Institut Curie Hospital, Department of Translational Research, Orsay, F-91405, France. Marie.dutreix@curie.fr) |
| Abstract | Approximately half of all cancer patients are treated with radiation therapy. However, some tumor cells can escape the lethal effects of irradiation by hypoxia, deregulation of the cell cycle or apoptosis or by increasing their ability to repair the DNA damage induced, resulting in recurrence of disease. In order to overcome these resistance mechanisms, various strategies have been developed. Over the last decade, extensive progress in human genomics and genetic tools has been made. Several methods using DNA or RNA molecules have been developed to target angiogenesis or other cellular functions in order to restore sensitivity to irradiation. In this review, we focus on five classes of nucleic acid-based approaches, (i) gene transfer by recombinant plasmid or virus, (ii) immune-stimulating oligonucleotides, (iii) antisense oligonucleotides, (iv) siRNA and shRNA, and (v) siDNA (signal interfering DNA), which target specific proteins or pathways involved in radioresistance. We review the results of the preclinical studies and clinical trials conducted to date by combining nucleic acid-based molecular therapy and radiotherapy. |
| File Format | HTM / HTML |
| ISSN | 13835718 |
| e-ISSN | 18793592 |
| Journal | Mutation Research/Genetic Toxicology and Environmental Mutagenesis |
| Issue Number | 1-3 |
| Volume Number | 704 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2010-04-01 |
| Publisher Place | Netherlands |
| Access Restriction | Open |
| Subject Keyword | Gene Transfer Techniques Genetic Therapy Dna Repair Discipline Genetics Oligonucleotides, Antisense Cell Proliferation Rna, Small Interfering Neovascularization, Pathologic Discipline Biochemistry Combined Modality Therapy Therapeutic Use Dna Damage Animals Immunotherapy Apoptosis |
| Content Type | Text |
| Resource Type | Article |
| Subject | Genetics Health, Toxicology and Mutagenesis |
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