NDLI: microRNA miR-10b inhibition reduces cell proliferation and promotes apoptosis in non-small cell lung cancer (NSCLC) cells.

Please wait, while we are loading the content...

Integration of pathway structure information into a reweighted partial Cox regression approach for survival analysis on high-dimensional gene expression data.

L-Asparaginase as a new molecular target against leishmaniasis: insights into the mechanism of action and structure-based inhibitor design.

A metabolomic study of adipose tissue in mice with a disruption of the circadian system.

Multiscale characterization of ageing and cancer progression by a novel network entropy measure.

MtHc: a motif-based hierarchical method for clustering massive 16S rRNA sequences into OTUs.

Predicting the binding modes and sites of metabolism of xenobiotics.

AAFreqCoil: a new classifier to distinguish parallel dimeric and trimeric coiled coils.

Metabolomics - the complementary field in systems biology: a review on obesity and type 2 diabetes.

Single-cell kinetics of a repressilator when implemented in a single-copy plasmid.

Insights into the binding mode of curcumin to MD-2: studies from molecular docking, molecular dynamics simulations and experimental assessments.

The PI3K/AKT/mTOR interactive pathway.

A system level analysis of gastric cancer across tumor stages with RNA-seq data.

Effects of culture media on metabolic profiling of the human gastric cancer cell line SGC7901.

Comparative studies on the inhibitory activities of selected benzoic acid derivatives against secretory phospholipase A2, a key enzyme involved in the inflammatory pathway.

Target specific proteochemometric model development for BACE1 - protein flexibility and structural water are critical in virtual screening.

Genome-wide transcriptional profiling analysis reveals annexin A6 as a novel EZH2 target gene involving gastric cellular proliferation.

SDRL: a sequence-dependent protein side-chain rotamer library.

Conformational analysis on the wild type and mutated forms of human ORF1p: a molecular dynamics study.

(1)H NMR brain metabonomics of scrapie exposed sheep.

Reproducibility of parameter learning with missing observations in naive Wnt Bayesian network trained on colorectal cancer samples and doxycycline-treated cell lines.

Mathematical modeling deciphers the benefits of alternatively-designed conserved activatory and inhibitory gene circuits.

Persulfides: Current Knowledge and Challenges in Chemistry and Chemical Biology

Study on the inter- and intra-peptide salt-bridge mechanism of Aß23-28 oligomer interaction with small molecules: QM/MM method.

An insight into antagonist binding and induced conformational dynamics of class B GPCR corticotropin-releasing factor receptor 1.

microRNA miR-10b inhibition reduces cell proliferation and promotes apoptosis in non-small cell lung cancer (NSCLC) cells.

Identifying the causative proteins of similar side effect pairs to explore the common molecular basis of these side effects.

Rough hypercuboid based supervised clustering of miRNAs.

Small-world networks of residue interactions in the Abl kinase complexes with cancer drugs: topology of allosteric communication pathways can determine drug resistance effects.

Protein localization vector propagation: a method for improving the accuracy of drug repositioning.

A miniaturized readout strategy for endogenous histone deacetylase activity.

Year: 2015 Volume: 11 Issue: 6

Year: 2015 Volume: 11 Issue: 5

Year: 2015 Volume: 11 Issue: 4

Year: 2015 Volume: 11 Issue: 3

Year: 2015 Volume: 11 Issue: 2

Year: 2015 Volume: 11 Issue: 1

Year: 2014 Volume: 10

microRNA miR-10b inhibition reduces cell proliferation and promotes apoptosis in non-small cell lung cancer (NSCLC) cells.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Huang, Junchao Sun, Chengchao Wang, Suqing He, Qiqiang Li, Dejia
Description	Country affiliation: China Author Affiliation: Huang J ( Hubei Province Key Laboratory on Cardiovascular, Cerebrovascular, and Metabolic Disorders, School of Nuclear Technology and Chemistry & Biology, Hubei University of Science and Technology, Xianning, 437100, China.)
Abstract	Lung cancer is one of the most common and serious types of cancer. Till now, the treatment of lung cancer has been unsatisfactory, which is associated with poor prognosis and high mortality. Therefore, there is an urgent requirement to investigate the molecular mechanisms underlying lung tumorigenesis. To study the potential function of miR-10b involved in the regulation of lung tumors, we monitored NSCLC cell behaviour including proliferation, apoptosis and cell cycle using CCK-8 and flow cytometry analysis. Real-time PCR was used to detect the expression levels of miR-10b in 75 NSCLC patients' tissues and Western blot was also used to analyze the expression level of genes correlated with apoptosis in NSCLC cells. miR-10b expression levels were higher in NSCLC tissues compared with an adjacent normal tissue control. Silencing of miR-10b inhibited cancer cell progress by arresting cell cycle progression in the G0/G1 phase and promoted apoptosis in NSCLC cells. Western blot analysis of miR-10b-silenced cells revealed up-regulation of apoptosis-inducing members Fas, FasL, Bax and caspase 3, and down-regulation of apoptosis-inhibiting factors Bcl-2 and PCNA. And, a significant inverse correlation between the level of miR-10b and klotho was observed, which has been demonstrated to be a novel tumor suppressor gene. A further in vivo tumor formation study in nude mice indicated that inhibition of miR-10b in lung cancer cells delayed the progress of tumor formation. These findings indicated that miR-10b might serve as a useful potential target for treatment of NSCLC.
File Format	HTM / HTML
ISSN	1742206X
Issue Number	7
Volume Number	11
e-ISSN	17422051
Journal	Molecular BioSystems
Language	English
Publisher	Royal Society of Chemistry
Publisher Date	2015-07-01
Publisher Place	Great Britain (UK)
Access Restriction	Subscribed
Subject Keyword	Discipline Molecular Biology Discipline Biochemistry Apoptosis Carcinoma, Non-small-cell Lung Genetics Lung Neoplasms Micrornas Animals Metabolism Mortality Cell Line, Tumor Cell Proliferation Female Gene Expression Gene Expression Regulation, Neoplastic Gene Knockdown Techniques Glucuronidase Humans Male Mice, Nude Middle Aged Neoplasm Transplantation Rna Interference Survival Analysis Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Molecular Biology Biotechnology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Decreased microRNA-132 and its function in human non-small cell lung cancer.

Knockdown of GINS2 inhibits proliferation and promotes apoptosis through the p53/GADD45A pathway in non-small-cell lung cancer.

MicroRNA-145 inhibits lung cancer cell metastasis.

miR-143 inhibits cell proliferation by targeting autophagy-related 2B in non-small cell lung cancer H1299 cells.

MicroRNA-15a induces cell apoptosis and inhibits metastasis by targeting BCL2L2 in non-small cell lung cancer.

Knockdown of lncRNA DLX6-AS1 inhibits cell proliferation, migration and invasion while promotes apoptosis by downregulating PRR11 expression and upregulating miR-144 in non-small cell lung cancer

MicroRNA-561 Affects Proliferation and Cell Cycle Transition Through PTEN/AKT Signaling Pathway by Targeting P-REX2a in NSCLC

The expression of heparanase and microRNA-1258 in human non-small cell lung cancer.

Differential expression of microRNAs and their target genes in non-small-cell lung cancer.

microRNA miR-10b inhibition reduces cell proliferation and promotes apoptosis in non-small cell lung cancer (NSCLC) cells.

Similar Documents

Decreased microRNA-132 and its function in human non-small cell lung cancer.

Knockdown of GINS2 inhibits proliferation and promotes apoptosis through the p53/GADD45A pathway in non-small-cell lung cancer.

MicroRNA-145 inhibits lung cancer cell metastasis.

miR-143 inhibits cell proliferation by targeting autophagy-related 2B in non-small cell lung cancer H1299 cells.

MicroRNA-15a induces cell apoptosis and inhibits metastasis by targeting BCL2L2 in non-small cell lung cancer.

Knockdown of lncRNA DLX6-AS1 inhibits cell proliferation, migration and invasion while promotes apoptosis by downregulating PRR11 expression and upregulating miR-144 in non-small cell lung cancer

MicroRNA-561 Affects Proliferation and Cell Cycle Transition Through PTEN/AKT Signaling Pathway by Targeting P-REX2a in NSCLC

The expression of heparanase and microRNA-1258 in human non-small cell lung cancer.

Differential expression of microRNAs and their target genes in non-small-cell lung cancer.

microRNA miR-10b inhibition reduces cell proliferation and promotes apoptosis in non-small cell lung cancer (NSCLC) cells.