NDLI: Metabolomics - the complementary field in systems biology: a review on obesity and type 2 diabetes.

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Metabolomics - the complementary field in systems biology: a review on obesity and type 2 diabetes.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Abu Bakar, Mohamad Hafizi Sarmidi, Mohamad Roji Cheng, Kian-Kai Ali Khan, Abid Suan, Chua Lee Zaman Huri, Hasniza Yaakob, Harisun
Description	Author Affiliation: Abu Bakar MH ( Department of Bioprocess Engineering, Faculty of Chemical Engineering, Universiti Teknologi Malaysia, 81310 Johor Bahru, Johor, Malaysia. mohamadhafizi88@gmail.com mhafizi55@live.utm.my.)
Abstract	Metabolomic studies on obesity and type 2 diabetes mellitus have led to a number of mechanistic insights into biomarker discovery and comprehension of disease progression at metabolic levels. This article reviews a series of metabolomic studies carried out in previous and recent years on obesity and type 2 diabetes, which have shown potential metabolic biomarkers for further evaluation of the diseases. Literature including journals and books from Web of Science, Pubmed and related databases reporting on the metabolomics in these particular disorders are reviewed. We herein discuss the potential of reported metabolic biomarkers for a novel understanding of disease processes. These biomarkers include fatty acids, TCA cycle intermediates, carbohydrates, amino acids, choline and bile acids. The biological activities and aetiological pathways of metabolites of interest in driving these intricate processes are explained. The data from various publications supported metabolomics as an effective strategy in the identification of novel biomarkers for obesity and type 2 diabetes. Accelerating interest in the perspective of metabolomics to complement other fields in systems biology towards the in-depth understanding of the molecular mechanisms underlying the diseases is also well appreciated. In conclusion, metabolomics can be used as one of the alternative approaches in biomarker discovery and the novel understanding of pathophysiological mechanisms in obesity and type 2 diabetes. It can be foreseen that there will be an increasing research interest to combine metabolomics with other omics platforms towards the establishment of detailed mechanistic evidence associated with the disease processes.
File Format	HTM / HTML
ISSN	1742206X
Issue Number	7
Volume Number	11
e-ISSN	17422051
Journal	Molecular BioSystems
Language	English
Publisher	Royal Society of Chemistry
Publisher Date	2015-07-01
Publisher Place	Great Britain (UK)
Access Restriction	Subscribed
Subject Keyword	Discipline Molecular Biology Discipline Biochemistry Diabetes Mellitus, Type 2 Metabolism Obesity Amino Acids Animals Bile Acids And Salts Carbohydrate Metabolism Choline Humans Lipid Metabolism Metabolomics Systems Biology Journal Article Research Support, Non-u.s. Gov't Review
Content Type	Text
Resource Type	Article
Subject	Molecular Biology Biotechnology

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The therapeutic potential of manipulating gut microbiota in obesity and type 2 diabetes mellitus.

Metabolomics analysis reveals that bile acids and phospholipids contribute to variable responses to low-temperature-induced ascites syndrome.

Probiotics--interactions with bile acids and impact on cholesterol metabolism.

Mechanisms of enterohepatic fibroblast growth factor 15/19 signaling in health and disease.

MicroRNAs and type 2 diabetes/obesity.

Bile-induced secretion of glucagon-like peptide-1: pathophysiological implications in type 2 diabetes?

Role of Intestinal Microbiome in Lipid and Glucose Metabolism in Diabetes Mellitus.

The role of bile acids in metabolic regulation.

Metabolomics - the complementary field in systems biology: a review on obesity and type 2 diabetes.

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