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PrP-associated resistance to scrapie in five highly infected goat herds.

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PrP-associated resistance to scrapie in five highly infected goat herds.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Corbière, Fabien Perrin-Chauvineau, Cécile Lacroux, Caroline Costes, Pierrette Thomas, Myriam Brémaud, Isabelle Martin, Samuel Lugan, Séverine Chartier, Christophe Schelcher, François Barillet, Francis Andreoletti, Olivier
Spatial Coverage	France
Description	Country affiliation: France Author Affiliation: Corbière F ( INRA, UMR 1225, Interactions Hôtes Agents Pathogènes, Ecole Nationale Vétérinaire de Toulouse, 23 Chemin des Capelles, Toulouse Cedex, France.)
Abstract	The PrP gene polymorphisms at codons 142 (I/M), 154 (R/H), 211 (R/Q), 222 (Q/K) and 240 (S/P) and their association with susceptibility to classical scrapie infection were investigated in five French goat herds displaying a high disease prevalence (>10%). On the basis of PrP(Sc) detection in the central nervous system and in various lymphoid tissues, 301 of 1343 goats were found to be scrapie infected. The statistical analyses indicated that while P(240) mutation had no direct impact on scrapie infection risk, the H(154), Q(211) and K(222) mutations were associated with high resistance to scrapie. The M(142) mutated allele was associated with a limited protection level against the disease. These results further reinforce the view that, like in sheep, the control and eradication of classical scrapie through the selection of certain PrP alleles could be envisaged in commercial goat population.
File Format	HTM / HTML
ISSN	00221317
Issue Number	Pt 1
Volume Number	94
e-ISSN	14652099
Journal	Journal of General Virology
Language	English
Publisher	Microbiology Society
Publisher Date	2013-01-01
Publisher Place	Great Britain (UK)
Access Restriction	Subscribed
Subject Keyword	Research Support, Non-u.s. Gov't Prevalence Scrapie Goats Discipline Virology Metabolism Genetic Predisposition To Disease Epidemiology Lymphoid Tissue Journal Article Goat Diseases Polymorphism, Genetic Animals Central Nervous System Immunology Prions Alleles Genetics Mutation France
Content Type	Text
Resource Type	Article
Subject	Virology

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Prion protein genotype survey confirms low frequency of scrapie-resistant K222 allele in British goat herds

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PRNP variants in goats reduce sensitivity of detection of PrP(Sc) by immunoassay.

Early accumulation of pathological PrP in the enteric nervous system and gut-associated lymphoid tissue of hamsters orally infected with scrapie

PrP-associated resistance to scrapie in five highly infected goat herds.

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PrP gene polymorphisms in Cyprus goats and their association with resistance or susceptibility to natural scrapie.

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Caprine PRNP polymorphisms at codons 171, 211, 222 and 240 in a Greek herd and their association with classical scrapie.

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PrP-associated resistance to scrapie in five highly infected goat herds.