NDLI: Human immunodeficiency virus type 1 gp120 envelope characteristics associated with disease progression differ in family members infected with genetically similar viruses.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Baan, Elly Van Der Sluis, Renée M. Bakker, Margreet E. Bekker, Vincent Pajkrt, Dasja Jurriaans, Suzanne Kuijpers, Taco W. Berkhout, Ben Wolthers, Katja C. Paxton, William A. Pollakis, Georgios
Description	Country affiliation: Netherlands Author Affiliation: Baan E ( Laboratory of Experimental Virology (LEV), Department of Medical Microbiology, Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center of the University of Amsterdam, Amsterdam, The Netherlands.)
Abstract	The human immunodeficiency virus type 1 (HIV-1) envelope protein provides the primary contact between the virus and host, and is the main target of the adaptive humoral immune response. The length of gp120 variable loops and the number of N-linked glycosylation events are key determinants for virus infectivity and immune escape, while the V3 loop overall positive charge is known to affect co-receptor tropism. We selected two families in which both parents and two children had been infected with HIV-1 for nearly 10 years, but who demonstrated variable parameters of disease progression. We analysed the gp120 envelope sequence and compared individuals that progressed to those that did not in order to decipher evolutionary alterations that are associated with disease progression when individuals are infected with genetically related virus strains. The analysis of the V3-positive charge demonstrated an association between higher V3-positive charges with disease progression. The ratio between the amino acid length and the number of potential N-linked glycosylation sites was also shown to be associated with disease progression with the healthier family members having a lower ratio. In conclusion in individuals initially infected with genetically linked virus strains the V3-positive charges and N-linked glycosylation are associated with HIV-1 disease progression and follow varied evolutionary paths for individuals with varied disease progression.
File Format	HTM / HTML
ISSN	00221317
Issue Number	Pt 1
Volume Number	94
e-ISSN	14652099
Journal	Journal of General Virology
Language	English
Publisher	Microbiology Society
Publisher Date	2013-01-01
Publisher Place	Great Britain (UK)
Access Restriction	Subscribed
Subject Keyword	Cd4-positive T-lymphocytes Discipline Virology Humans Child, Preschool Male Glycosylation Hiv Infections Phylogeny Rna, Viral Metabolism Amino Acids Disease Progression Journal Article Virology Hiv-1 Immunology Hiv Envelope Protein Gp120 Genetics Adult Family Female Dna Barcoding, Taxonomic Methods
Content Type	Text
Resource Type	Article
Subject	Virology

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