NDLI: PrP gene polymorphisms in Cyprus goats and their association with resistance or susceptibility to natural scrapie.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Papasavva-Stylianou, Penelope Windl, Otto Saunders, Ginny Mavrikiou, Petroula Toumazos, Pavlos Kakoyiannis, Charalambos
Spatial Coverage	Cyprus
Description	Country affiliation: Cyprus Author Affiliation: Papasavva-Stylianou P ( TSE Section, Laboratory of Animal Health, State Veterinary Laboratories, Veterinary Services, 1417 Nicosia, Cyprus. pstylianou@vs.moa.gov.cy)
Abstract	In contrast to scrapie in sheep, the genetic basis of susceptibility to scrapie in goats is not well understood. To study the association of prion protein (PrP) alleles with susceptibility to scrapie in goats in Cyprus, the coding sequence of the caprine PrP gene was determined in 717 goats, including 218 scrapie positive animals. Several novel polymorphisms were detected, such as a novel octarepeat variant and a stop codon mutation. Amino acids at codons 146 and 154 were associated with susceptibility to goat scrapie. Animals heterozygous for serine (S) and aspartate (D) at codon 146 were significantly under-represented in scrapie positive animals and no positive animals were found that were homozygous for these amino acids at codon 146. These results might provide the basis for genetic control of scrapie in Cypriot goats.
File Format	HTM / HTML
ISSN	10900233
Issue Number	2
Volume Number	187
e-ISSN	15322971
Journal	The Veterinary Journal
Language	English
Publisher	Elsevier
Publisher Date	2011-02-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Research Support, Non-u.s. Gov't Goats Scrapie Cyprus Discipline Veterinary Medicine Genotype Genetic Predisposition To Disease Sequence Analysis, Dna Amino Acids Journal Article Goat Diseases Polymorphism, Genetic Case-control Studies Animals Codon Prions Alleles Genetics Veterinary
Content Type	Text
Resource Type	Article
Subject	Veterinary Animal Science and Zoology

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