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Postmortem detection of isopropanol in ketoacidosis.

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Postmortem detection of isopropanol in ketoacidosis.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Petersen, Thomas H. Williams, Timothy Nuwayhid, Naziha Harruff, Richard
Description	Country affiliation: United States Author Affiliation: Petersen TH ( Duke Univeristy School of Medicine, Duke University Medical Center, Durham, NC 27710, USA.)
Abstract	Isopropanol (IPA) detected in deaths because of diabetic ketoacidosis (DKA) or alcoholic ketoacidosis (AKA) may cause concern for IPA poisoning. This study addressed this concern in a 15-year retrospective review of 260 deaths in which concentrations of acetone and IPA, as well as their ratios, were compared in DKA (175 cases), AKA (79 cases), and IPA intoxication (six cases). The results demonstrated the frequency of detecting IPA in ketoacidosis when there was no evidence of IPA ingestion. IPA was detectable in 77% of DKA cases with quantifiable concentrations averaging 15.1 ± 13.0 mg/dL; 52% of AKA cases with quantifiable concentrations averaging 18.5 ± 22.1 mg/dL; and in cases of IPA intoxication, averaging 326 ± 260 mg/dL. There was weak correlation of IPA production with postmortem interval in DKA only (r = -0.48). Although IPA concentrations were much higher with ingestion, potentially toxic concentrations were achievable in DKA without known ingestion.
File Format	HTM / HTML
ISSN	00221198
Issue Number	3
Volume Number	57
e-ISSN	15564029
Journal	Journal of Forensic Sciences
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2012-05-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Solvents Diagnosis, Differential 2-propanol Ethanol Biological Markers Humans Middle Aged Male Discipline Forensic Sciences Forensic Toxicology Ketosis Blood Journal Article Central Nervous System Depressants Flame Ionization Female Forensic Pathology Poisoning Retrospective Studies Diagnosis Postmortem Changes Acetone
Content Type	Text
Resource Type	Article
Subject	Genetics Pathology and Forensic Medicine

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