NDLI: Surface modification of ultrahigh molecular weight polyethylene by the poly(ethylene glycol)-grafted method and its effect on the adsorption of proteins and the adhesion of blood platelets.

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Surface modification of ultrahigh molecular weight polyethylene by the poly(ethylene glycol)-grafted method and its effect on the adsorption of proteins and the adhesion of blood platelets.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Xia, Bing Xie, Meiju Yang, Bangcheng
Description	Country affiliation: China Author Affiliation: Xia B ( Engineering Research Center for Biomaterials, Sichuan University, Chengdu, Sichuan 610064, China.)
Abstract	With the help of a silane coupling agent, poly(ethylene glycol) (PEG), a well-biocompatable agent, was grafted onto the surface of ultrahigh molecular weight polyethylene (UHMWPE) by ultraviolet initiation. Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy analysis proved the success of PEG grafting. Water contact angle measurement showed that the modified UHMWPE was obviously improved in surface hydrophilicity and thermogravimetric analysis result showed that its thermostability did not decline even it was pretreated by strong acids. Then, the protein adsorption of the modified UHMWPE was investigated using three model proteins including bovine serum albumin, lysozyme, and fibrinogen. Rabbit blood was used to study the platelet adhesion on the surface of modified UHMWPE. The results indicated that the quantity of protein adsorption on the modified UHMWPE grafted PEG reduced apparently for all the model proteins while there was some specific differences or exceptions among them. It was ascribed to the changed surface chemical composition, surface hydrophilicity and surface topography after modification. The adhesive ability of blood platelets on the modified surface of UHMWPE decreased after PEG grafting. Owing to the improved resistance to fibrinogen adsorption and platelet adhesion, the surface modification might endow the UHWMPE surface better anticoagulation ability according to clotting mechanism.
File Format	HTM / HTML
ISSN	15493296
Issue Number	1
Volume Number	101
e-ISSN	15524965
Journal	Journal of Biomedical Materials Research Part A
Language	English
Publisher	Wiley
Publisher Date	2013-01-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Water Platelet Adhesiveness Polyethylenes Photoelectron Spectroscopy Rabbits Research Support, Non-u.s. Gov't Microscopy, Electron, Scanning X-ray Diffraction Polyethylene Glycols Blood Platelets Crystallization Thermogravimetry Pharmacology Metabolism Spectroscopy, Fourier Transform Infrared Drug Effects Journal Article Discipline Biomedical Engineering Chemistry Animals Adsorption Serum Albumin, Bovine Cattle Surface Properties
Content Type	Text
Resource Type	Article
Subject	Ceramics and Composites Metals and Alloys Biomaterials Biomedical Engineering

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