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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Wu, Ming-Hsiu Pan, Tzu-Ming Wu, Yu-Jen Chang, Sue-Joan Chang, Ming-Song Hu, Chun-Yi |
| Description | Country affiliation: Taiwan Author Affiliation: Wu MH ( Department of Nutrition and Health Science, Fooyin University, Kaohsiung County, Taiwan.) |
| Abstract | Exopolysaccharides (EPSs) are a metabolite of probiotics which have gained wide interest recently, but little is known about their function. EPS was isolated from Bifidobacterium longum BCRC 14634 and sterilized by 0.22 µm filter. The proliferation of J77A.1 macrophages and their secretion of the anti-inflammatory cytokine interleukin-10 (IL-10) was elevated after treatment with heat-killed B. longum or 5 µg/mL EPS. The endotoxin, lipopolysaccharides (LPS), a potent inducer of pro-inflammatory cytokine tumor necrosis factor- (TNF- ), significantly suppressed the growth of J77A.1 cells, and induced the secretion of TNF- from J774A.1 cells. Furthermore, 24h pretreatment with 5 µg/ml EPS suppressed 100 ng/ml LPS-induced cell growth inhibition and release of TNF- from J774A.1 cells. Additional experiments showed that 80 µg/mL EPS had antimicrobial activity against 7 species of food-spoilage and infection bacteria. Our results suggest that EPS from B. longum might be useful as a mild immune modulator for macrophages, contributing to the capacity of B. longum to fight against gastrointestinal infections, and even some food-spoilage microbe. |
| File Format | HTM / HTML |
| ISSN | 01681605 |
| Issue Number | 1 |
| Volume Number | 144 |
| e-ISSN | 18793460 |
| Journal | International Journal of Food Microbiology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2010-11-15 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Immunologic Factors Cell Line Research Support, Non-u.s. Gov't Discipline Microbiology Anti-infective Agents Bifidobacterium Cell Proliferation Polysaccharides, Bacterial Interleukin-10 Gene Expression Regulation Isolation & Purification Pharmacology Macrophages Metabolism Drug Effects Tumor Necrosis Factor-alpha Journal Article Lipopolysaccharides Probiotics Chemistry Animals Immunology Mice Discipline Nutritional Sciences |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Microbiology Safety, Risk, Reliability and Quality Food Science |
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