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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Watterlot, Laurie Rochat, Tatiana Sokol, Harry Cherbuy, Claire Bouloufa, Ismael Lefèvre, François Gratadoux, Jean-Jacques Honvo-Hueto, Edith Chilmonczyk, Stefan Blugeon, Sébastien Corthier, Gérard Langella, Philippe Bermúdez-Humarán, Luis G. |
| Description | Country affiliation: France Author Affiliation: Watterlot L ( Unité d'Ecologie et de Physiologie du Système Digestif, Domaine de Vilvert, 78352 Jouy-en-Josas cedex, France.) |
| Abstract | Human immune cells release large amounts of reactive oxygen species (ROS) such as superoxide radical and hydrogen peroxide via respiratory burst. In inflammatory bowel diseases, a sustained and abnormal activation of the immune response results in oxidative stress of the digestive tract and in a loss of intestinal homeostasis. We previously reported that heterologous production of the Lactobacillus plantarum manganese catalase (MnKat) enhances the survival of Lb. casei BL23 when exposed to oxidative stress. Anti-inflammatory effects were observed after Lb. casei BL23 oral administrations in moderate murine dextran sodium sulfate (DSS)-induced colitis, without added effects of the MnKat production. Here, we evaluated the protective effects obtained by an improved antioxidative strategy. The Lactococcus lactis sodA gene was expressed in Lb. casei BL23 which acquired an efficient manganese superoxide dismutase (MnSOD) activity. The effects of Lb. casei MnSOD alone or in combination with Lb. casei MnKat were compared first in eukaryotic cell PMA-induced oxidative stress model and then in severe murine DSS-induced colitis. Based on ROS production assays as well as colonic histological scores, a significant reduction of both oxidative stress and inflammation was observed with Lb. casei MnSOD either alone or in combination with Lb. casei MnKat. No added effect of the presence of Lb. casei MnKat was observed. These results suggest that Lb. casei BL23 MnSOD could have anti-inflammatory effects on gut inflammation. |
| File Format | HTM / HTML |
| ISSN | 01681605 |
| Issue Number | 1 |
| Volume Number | 144 |
| e-ISSN | 18793460 |
| Journal | International Journal of Food Microbiology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2010-11-15 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Therapy Dextran Sulfate Research Support, Non-u.s. Gov't Microbiology Oxidative Stress Humans Mice, Inbred Balb C Male Recombinant Proteins Journal Article Catalase Anti-inflammatory Agents Genetics Lactobacillus Casei Colon Discipline Microbiology Cells, Cultured Inflammation Metabolism Therapeutic Use Chemically Induced Pathology Animals Mice Colitis Discipline Nutritional Sciences Enzymology Lactococcus Lactis Superoxide Dismutase |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Microbiology Safety, Risk, Reliability and Quality Food Science |
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