NDLI: Using cytochrome P4501A1 expression in liver and blubber to understand effects of persistent organic pollutant exposure in stranded Pacific Island cetaceans.

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Using cytochrome P4501A1 expression in liver and blubber to understand effects of persistent organic pollutant exposure in stranded Pacific Island cetaceans.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Bachman, Melannie J. Foltz, Kerry M. Lynch, Jennifer M. West, Kristi L. Jensen, Brenda A.
Spatial Coverage	Pacific Islands
Description	Country affiliation: United States Author Affiliation: Bachman MJ ( Department of Natural Sciences, Hawaii Pacific University, Kaneohe, Hawaii, USA.); Foltz KM ( Hollings Marine Laboratory, Chemical Sciences Division, National Institute of Standards and Technology, Charleston, South Carolina, USA.); Lynch JM ( Department of Natural Sciences, Hawaii Pacific University, Kaneohe, Hawaii, USA.); West KL ( Hollings Marine Laboratory, Chemical Sciences Division, National Institute of Standards and Technology, Charleston, South Carolina, USA.); Jensen BA ( Department of Natural Sciences, Hawaii Pacific University, Kaneohe, Hawaii, USA.)
Abstract	Elevated levels of persistent organic pollutants (POPs) have been reported in tropical Pacific Island cetaceans and their environment. In addition, recent health concerns in cetacean populations have warranted investigation into potential physiological effects from POP exposure for this region. Cytochrome P450 1A1 (CYP1A1) is a candidate for examining such effects. This well-studied biomarker of exposure and effect was examined in stranded cetacean liver using immunoblot (n = 39, 16 species) and blubber using immunohistochemistry (n = 23, 10 species). Paired tissue samples allowed for CYP1A1 comparisons not only between species but also within each individual animal to examine differences between tissue types. Liver CYP1A1 expression correlated positively and significantly with blubber concentrations of all POP categories (n = 39, p < 0.050) except octachlorostyrene and pentachlorobenzene (p > 0.100). Among Stenella species, liver CYP1A1 tissue expression was correlated negatively with the sum of all blubber layer endothelial cell CYP1A1 expression (n = 14, p = 0.049). Overall, elevated expression of liver CYP1A1 confirms its use as a biomarker of POP exposure to cetaceans stranded in the tropical Pacific basin.
File Format	HTM / HTML
ISSN	07307268
Issue Number	9
Volume Number	34
e-ISSN	15528618
Journal	Environmental Toxicology and Chemistry
Language	English
Publisher	Wiley
Publisher Date	2015-09-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Water Pollutants, Chemical Immunohistochemistry Research Support, U.s. Gov't, Non-p.h.s. Organic Chemicals Toxicity Discipline Environmental Health Liver Pacific Islands Discipline Toxicology Cytochrome P-450 Cyp1a1 Immunoblotting Metabolism Drug Effects Journal Article Chemistry Animals Up-regulation Discipline Chemistry Cetacea Adipose Tissue
Content Type	Text
Resource Type	Article
Subject	Environmental Chemistry Health, Toxicology and Mutagenesis

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