NDLI: Short-term fish reproduction assays with methyl tertiary butyl ether with zebrafish and fathead minnow: Implications for evaluation of potential for endocrine activity.

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Short-term fish reproduction assays with methyl tertiary butyl ether with zebrafish and fathead minnow: Implications for evaluation of potential for endocrine activity.

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Short-term fish reproduction assays with methyl tertiary butyl ether with zebrafish and fathead minnow: Implications for evaluation of potential for endocrine activity.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Mihaich, Ellen Erler, Steffen Le Blanc, Gerald Gallagher, Sean
Description	Country affiliation: United States Author Affiliation: Mihaich E ( Environmental and Regulatory Resources, Durham, North Carolina, USA.); Erler S ( SABIC, Saudi Basic Industries Corporation, Pittsfield, Massachusettes, USA.); Le Blanc G ( Department of Biological Sciences, North Carolina State University, Raleigh, North Carolina, USA.); Gallagher S ( Wildlife International, Easton, Maryland, USA.)
Abstract	The authors report on short-term fish reproduction assays in zebrafish and fathead minnow conducted to examine the potential for methyl tertiary butyl ether (MTBE) to cause effects on the endocrine system. Both studies were performed under good laboratory practice and in accordance with Organisation for Economic Co-operation and Development and US Environmental Protection Agency test guidelines. The results of the first study demonstrated that exposure to a high test concentration (147 mg/L) of MTBE impaired reproductive output of female zebrafish, evident by a reduction in fecundity. Based on the endpoints evaluated in the present study however, there was no supporting evidence to indicate that this effect was caused by disruption of or interaction with the endocrine system. In the second study, fathead minnows exposed to a wider but lower range of test concentrations showed no effects on any reproductive parameter of male or female fish, at the maximum recommended testing concentration of 100 mg/L (62 mg/L measured). The results of these 2 guideline studies indicate that MTBE does not interact with the hypothalamic-pituitary-gonadal axis of zebrafish or fathead minnow.
File Format	HTM / HTML
ISSN	07307268
Issue Number	9
Volume Number	34
e-ISSN	15528618
Journal	Environmental Toxicology and Chemistry
Language	English
Publisher	Wiley
Publisher Date	2015-09-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Water Pollutants, Chemical Research Support, Non-u.s. Gov't Toxicity Discipline Environmental Health Methyl Ethers Discipline Toxicology Zebrafish Male Metabolism Drug Effects Endocrine System Enzyme-linked Immunosorbent Assay Blood Journal Article Growth & Development Chemistry Reproduction Animals Fertility Discipline Chemistry Female Physiology Vitellogenins Cyprinidae
Content Type	Text
Resource Type	Article
Subject	Environmental Chemistry Health, Toxicology and Mutagenesis

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