NDLI: Tracking multiple modes of endocrine activity in Australia's largest inland sewage treatment plant and effluent- receiving environment using a panel of in vitro bioassays.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Roberts, Jenna Bain, Peter A. Kumar, Anupama Hepplewhite, Christopher Ellis, David J. Christy, Andrew G. Beavis, Sara G.
Spatial Coverage	Australia
Description	Country affiliation: Australia Author Affiliation: Roberts J ( CSIRO, Land and Water, Glen Osmond, South Australia, Australia.); Bain PA ( Research School of Earth Sciences, Australian National University, Acton, Australian Capital Territory, Australia.); Kumar A ( CSIRO, Land and Water, Glen Osmond, South Australia, Australia.); Hepplewhite C ( CSIRO, Land and Water, Glen Osmond, South Australia, Australia.); Ellis DJ ( Canberra, Australian Capital Territory, Australia.); Christy AG ( Research School of Earth Sciences, Australian National University, Acton, Australian Capital Territory, Australia.); Beavis SG ( Research School of Earth Sciences, Australian National University, Acton, Australian Capital Territory, Australia.)
Abstract	Estrogenicity of sewage effluents, and related ecotoxicological effects in effluent-receiving environments, have been widely reported over the last 2 decades. However, relatively little attention has been given to other endocrine pathways that may be similarly disrupted by a growing list of contaminants of concern. Furthermore, the Australian evidence base is limited compared with those of Europe and North America. During a low dilution period in summer, the authors investigated multiple endocrine potencies in Australia's largest inland sewage treatment plant (STP) and the Lower Molonglo/Upper Murrumbidgee effluent-receiving environment. This STP receives 900 L/s of mostly domestic wastewater from a population of 350 000, and contributes a high proportion of total flow in the lower catchment during dry periods. A panel of in vitro receptor-driven transactivation assays were used to detect (anti)estrogenic, (anti) androgenic, (anti)progestagenic, glucocorticoid, and peroxisome-proliferator activity at various stages of the sewage treatment process. Total estrogenic and (anti)androgenic potency was removed after primary and/or secondary treatment; however, total removal efficiency for glucocorticoid potency was poorer (53-66%), and progestagenic potency was found to increase along the treatment train. Estrogenicity was detected in surface waters and bed sediments upstream and downstream of the effluent outfall, at maximum levels 10 times lower than low-hazard thresholds. Glucocorticoid and progestagenic activity were found to persist to 4 km downstream of the effluent outfall, suggesting that future research is needed on these endocrine-disrupting chemical categories in effluent-receiving systems.
File Format	HTM / HTML
ISSN	07307268
Issue Number	10
Volume Number	34
e-ISSN	15528618
Journal	Environmental Toxicology and Chemistry
Language	English
Publisher	Wiley
Publisher Date	2015-10-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Water Pollutants, Chemical Geography Research Support, Non-u.s. Gov't Discipline Environmental Health Humans Discipline Toxicology Receptors, Cell Surface Waste Disposal, Fluid Water Purification Metabolism Carbon Endocrine Disruptors Journal Article Geologic Sediments Chemistry Sewage Ppar Gamma Analysis Discipline Chemistry Biological Assay Environment Australia Methods
Content Type	Text
Resource Type	Article
Subject	Environmental Chemistry Health, Toxicology and Mutagenesis

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