NDLI: Prevalence and risk factors for disrupted circadian rhythmicity in children with optic nerve hypoplasia.

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Prevalence and risk factors for disrupted circadian rhythmicity in children with optic nerve hypoplasia.

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Prevalence and risk factors for disrupted circadian rhythmicity in children with optic nerve hypoplasia.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Rivkees, S. A. Fink, C. Nelson, M. Borchert, M.
Description	Country affiliation: United States Author Affiliation: Rivkees SA ( Department of Pediatrics, Yale Child Health Research Center, 464 Congress Avenue, New Haven CT 06520, USA. scott.rivkees@yale.edu)
Abstract	BACKGROUND/AIMS: Children with optic nerve hypoplasia (ONH) have visual impairment and may have hypopituitarism and developmental delay. Children with ONH have also been reported to have abnormal sleep-wake cycles. We assessed the incidence and nature of sleep-wake abnormalities in children with ONH. METHODS: Rest-activity patterns were assessed in 23 children with ONH using actigraphy, which is a non-invasive method for continuously monitoring activity. The children also had formal assessment of pituitary function, visual acuity measurements, assessment of papillary responsiveness, MRI scans of the head and assessment of neurocognitive function. RESULTS: Sufficient actigraphy data were obtained on 19 of the children. Analysis of expressed rhythmicity revealed normal rest-activity patterns in 13 children (68%). Of the six children (32%) with abnormal rhythmicity, three had fragmented sleep, one had free-running rest-activity cycles and two were arrhythmic. Of the children with normal rhythmicity, the following were found: hypoplastic corpus callosum in 30%, growth hormone deficiency in 53%, hypothyroidism in 23%, adrenal insufficiency in 30%, diabetes insipidus in 0% and developmental delay in 15%. Of the children with abnormal rhythmicity, the following were found: hypoplastic corpus callosum in 66% (p>0.05), severe visual impairment in 100% (p=0.006), abnormal pupillary responsiveness in 85% (p=0.0084), cognitive impairment in 100% (p=0.04) and multiple hormonal deficiencies in 66% (p=0.03). CONCLUSIONS: Abnormal rest-activity rhythmicity patterns are present in 30% of children with ONH. The best predictors of abnormal rhythmicity are severe vision impairment, abnormal pupillary responsiveness, developmental delay and multiple hormonal deficiencies.
File Format	HTM / HTML
ISSN	00071161
Issue Number	10
Volume Number	94
e-ISSN	14682079
Journal	British Journal of Ophthalmology
Language	English
Publisher	BMJ Publishing Group Ltd.
Publisher Date	2010-10-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Research Support, N.i.h., Extramural Developmental Disabilities Research Support, Non-u.s. Gov't Optic Nerve Abnormalities Humans Risk Factors Sleep Disorders Child, Preschool Circadian Rhythm Journal Article Pupil Discipline Ophthalmology Magnetic Resonance Imaging Rest Cognition Disorders Etiology Vision Disorders Physiology
Content Type	Text
Resource Type	Article
Subject	Ophthalmology Sensory Systems Cellular and Molecular Neuroscience

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