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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Kiener, Hans P. Niederreiter, Birgit Lee, David M. Jimenez-Boj, Esther Smolen, Josef S. Brenner, Michael B. |
| Description | Country affiliation: United States Author Affiliation: Kiener HP ( Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts 02115, USA.) |
| Abstract | OBJECTIVE: To define the expression pattern of cadherin 11 in the destructive pannus tissue of patients with rheumatoid arthritis, and to determine whether cadherin 11 expression in fibroblast-like synoviocytes controls their invasive capacity. METHODS: Cadherin 11 expression in rheumatoid synovial tissue was evaluated using immunohistochemistry. To examine the role of cadherin 11 in regulating the invasive behavior of fibroblast-like synoviocytes, we generated L cell clones expressing wild-type cadherin 11, mutant cadherin 11, and empty vector-transfected controls. The invasive capacity of L cell transfectants and cultured fibroblast-like synoviocytes treated with a blocking cadherin 11-Fc fusion protein or control immunoglobulin was determined in Matrigel invasion assays. RESULTS: Immunohistochemical analysis revealed that cadherin 11 is abundantly expressed in cells at the cartilage-pannus junction in rheumatoid synovitis. Assays to determine invasion demonstrated a 2-fold increased invasive capacity of cadherin 11-transfected L cells compared with L cells transfected with E-cadherin or control vector. The invasive behavior of L cells stably transfected with a cadherin 11 construct that lacked the juxtamembrane cytoplasmic domain was diminished to the level of vector control L cells. Furthermore, treatment with the cadherin 11-Fc fusion protein diminished the invasive capacity of fibroblast-like synoviocytes. CONCLUSION: The results of these in vitro studies implicate a role for cadherin 11 in promoting cell invasion and contribute insight into the invasive nature of fibroblast-like synoviocytes in chronic synovitis and rheumatoid arthritis. |
| File Format | HTM / HTML |
| ISSN | 00043591 |
| e-ISSN | 15290131 |
| DOI | 10.1002/art.24453 |
| Journal | Arthritis & Rheumatism |
| Issue Number | 5 |
| Volume Number | 60 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2009-05-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Immunohistochemistry Research Support, N.i.h., Extramural Synovitis Research Support, Non-u.s. Gov't Cytology Arthritis, Rheumatoid Pathology Animals Transfection Fibroblasts Cadherins Genetics Physiology Synovial Membrane Mice Mutation Discipline Rheumatic Diseases L Cells (cell Line) |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology Pharmacology (medical) Rheumatology |
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