NDLI: Premature atherosclerosis in pediatric systemic lupus erythematosus: risk factors for increased carotid intima-media thickness in the atherosclerosis prevention in pediatric lupus erythematosus cohort.

Please wait, while we are loading the content...

Cartilage repair in a rat model of osteoarthritis through intraarticular transplantation of muscle-derived stem cells expressing bone morphogenetic protein 4 and soluble Flt-1.

Regulation of autophagy in human and murine cartilage: hypoxia-inducible factor 2 suppresses chondrocyte autophagy.

Induction of CCR2-dependent macrophage accumulation by oxidized phospholipids in the air-pouch model of inflammation.

Chlamydiae as etiologic agents in chronic undifferentiated spondylarthritis.

Clinical images: Cement embolism following percutaneous vertebroplasty.

Association of interleukin-1 receptor antagonist and interleukin-6 polymorphisms with osteolysis after total hip arthroplasty: comment on the article by Gordon et al.

The PRL -1149 G/T polymorphism and rheumatoid arthritis susceptibility.

Premature atherosclerosis in pediatric systemic lupus erythematosus: risk factors for increased carotid intima-media thickness in the atherosclerosis prevention in pediatric lupus erythematosus cohort.

Regulation of pulmonary inflammation and fibrosis through expression of integrins alphaVbeta3 and alphaVbeta5 on pulmonary T lymphocytes.

Down-regulation of myeloid cell leukemia 1 by epigallocatechin-3-gallate sensitizes rheumatoid arthritis synovial fibroblasts to tumor necrosis factor alpha-induced apoptosis.

Gene expression profiling in neutrophils from children with polyarticular juvenile idiopathic arthritis.

Cadherin 11 promotes invasive behavior of fibroblast-like synoviocytes.

The dynamics of macrophage lineage populations in inflammatory and autoimmune diseases.

Should patients with rheumatoid arthritis receive statin therapy?

Effect of ciprofloxacin-mediated inhibition on cell proliferation in rat tendon cells: Comment on the article.

Clinical images: Podoconiosis: foot edema resulting from regional geochemistry.

Clinical images: Gout attack and stiff knee in an airline passenger in economy class.

Mann-Whitney U test and Kruskal-Wallis test should be used for comparisons of differences in medians, not means: comment on the article by van der Helm-van Mil et al.

Year: 2009 Volume: 60 Issue: 4

Year: 2009 Volume: 60 Issue: 3

Year: 2009 Volume: 60 Issue: 2

Year: 2009 Volume: 60 Issue: 1

Year: 2008 Volume: 59

Year: 2008 Volume: 58

Year: 2007 Volume: 57

Year: 2007 Volume: 56

Year: 2006 Volume: 55

Year: 2006 Volume: 54

Year: 2005 Volume: 53

Year: 2005 Volume: 52

Year: 2004 Volume: 51

Year: 2004 Volume: 50

Year: 2003 Volume: 48

Year: 2002 Volume: 46

Year: 2001 Volume: 44

Year: 2000 Volume: 43

Premature atherosclerosis in pediatric systemic lupus erythematosus: risk factors for increased carotid intima-media thickness in the atherosclerosis prevention in pediatric lupus erythematosus cohort.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Schanberg, Laura E. Sandborg, Christy Barnhart, Huiman X. Ardoin, Stacy P. Yow, Eric Evans, Gregory W. Mieszkalski, Kelly L. Ilowite, Norman T. Eberhard, Anne Levy, Deborah M. Kimura, Yukiko Von Scheven, Emily Silverman, Earl Bowyer, Suzanne L. Punaro, Lynn Singer, Nora G. Sherry, David D. McCurdy, Deborah Klein-Gitelman, Marissa Wallace, Carol Silver, Richard Wagner-Weiner, Linda Higgins, Gloria C. Brunner, Hermine I. Jung, Lawrence Soep, Jennifer B. Reed, Ann
Description	Country affiliation: United States Author Affiliation: Schanberg LE ( Duke University Medical Center, Durham, North Carolina 27710, USA. schan001@mc.duke.edu)
Abstract	OBJECTIVE: To evaluate risk factors for subclinical atherosclerosis in a population of patients with pediatric systemic lupus erythematosus (SLE). METHODS: In a prospective multicenter study, a cohort of 221 patients underwent baseline measurements of carotid intima-media thickness (CIMT) as part of the Atherosclerosis Prevention in Pediatric Lupus Erythematosus (APPLE) trial. SLE disease measures, medications, and traditional risk factors for atherosclerosis were assessed. A standardized protocol was used to assess the thickness of the bilateral common carotid arteries and the mean maximal IMT of 12 segments. Univariable analysis identified potential associations with CIMT, which were examined in multivariable linear regression modeling. RESULTS: Based on the mean-mean common or the mean-max CIMT as the dependent variable, univariable analysis showed significant associations of the following variables with increased CIMT: increasing age, longer SLE duration, minority status, higher body mass index (BMI), male sex, increased creatinine clearance, higher lipoprotein(a) level, proteinuria, azathioprine treatment, and prednisone dose. In multivariable modeling, both azathioprine use (P=0.005 for the mean-mean model and P=0.102 for the mean-max model) and male sex (P<0.001) were associated with increases in the mean-max CIMT. A moderate dosage of prednisone (0.15-0.4 mg/kg/day) was associated with decreases in the mean-max CIMT (P=0.024), while high-dose and low-dose prednisone were associated with increases in the mean-mean common CIMT (P=0.021) and the mean-max CIMT (P=0.064), respectively. BMI (P<0.001) and creatinine clearance (P=0.031) remained associated with increased mean-mean common CIMT, while increasing age (P<0.001) and increasing lipoprotein(a) level (P=0.005) were associated with increased mean-max CIMT. CONCLUSION: Traditional as well as nontraditional risk factors were associated with increased CIMT in this cohort of patients in the APPLE trial. Azathioprine treatment was associated with increased CIMT. The relationship between CIMT and prednisone dose may not be linear.
File Format	HTM / HTML
ISSN	00043591
e-ISSN	15290131
DOI	10.1002/art.24469
Journal	Arthritis & Rheumatism
Issue Number	5
Volume Number	60
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2009-05-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Prospective Studies Tunica Intima Blood Etiology Lupus Erythematosus, Systemic Atherosclerosis Carotid Artery, Common Ultrasonography Body Mass Index Creatinine Adverse Effects Prevention & Control Complications Risk Factors Drug Therapy Prednisone Metabolism Therapeutic Use Lipoproteins Adolescent Sex Factors Multicenter Study Azathioprine Discipline Rheumatic Diseases
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology Pharmacology (medical) Rheumatology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Understanding Premature Atherosclerosis in Pediatric SLE: Risk Factors of Increased Carotid Intima Medial Thickness (CIMT) in the Atherosclerosis Prevention in Pediatric Lupus Erythematosus (APPLE) Cohort

Preclinical atherosclerosis due to HIV infection: carotid intima-medial thickness measurements from the FRAM study.

Dysfunctional proinflammatory high-density lipoproteins confer increased risk of atherosclerosis in women with systemic lupus erythematosus.

Plasma osteopontin versus intima media thickness of the common carotid arteries in well-characterised patients with systemic lupus erythematosus

Differences in atherosclerosis according to area level socioeconomic deprivation: cross sectional, population based study

Common carotid intima-media thickness and framingham risk score predict incident carotid atherosclerotic plaque formation: longitudinal results from the study of health in Pomerania.

Association between carotid intima-media thickness and pericardial fat in the Multi-Ethnic Study of Atherosclerosis (MESA).

Common carotid artery intima-media thickness: the Cardiovascular Risk Factor Multiple Evaluation in Latin America (CARMELA) study results.

Carotid artery intima-media thickness and HIV infection: traditional risk factors overshadow impact of protease inhibitor exposure.

Premature atherosclerosis in pediatric systemic lupus erythematosus: risk factors for increased carotid intima-media thickness in the atherosclerosis prevention in pediatric lupus erythematosus cohort.

Similar Documents

Understanding Premature Atherosclerosis in Pediatric SLE: Risk Factors of Increased Carotid Intima Medial Thickness (CIMT) in the Atherosclerosis Prevention in Pediatric Lupus Erythematosus (APPLE) Cohort

Preclinical atherosclerosis due to HIV infection: carotid intima-medial thickness measurements from the FRAM study.

Dysfunctional proinflammatory high-density lipoproteins confer increased risk of atherosclerosis in women with systemic lupus erythematosus.

Plasma osteopontin versus intima media thickness of the common carotid arteries in well-characterised patients with systemic lupus erythematosus

Differences in atherosclerosis according to area level socioeconomic deprivation: cross sectional, population based study

Common carotid intima-media thickness and framingham risk score predict incident carotid atherosclerotic plaque formation: longitudinal results from the study of health in Pomerania.

Association between carotid intima-media thickness and pericardial fat in the Multi-Ethnic Study of Atherosclerosis (MESA).

Common carotid artery intima-media thickness: the Cardiovascular Risk Factor Multiple Evaluation in Latin America (CARMELA) study results.

Carotid artery intima-media thickness and HIV infection: traditional risk factors overshadow impact of protease inhibitor exposure.

Premature atherosclerosis in pediatric systemic lupus erythematosus: risk factors for increased carotid intima-media thickness in the atherosclerosis prevention in pediatric lupus erythematosus cohort.