NDLI: Chlamydiae as etiologic agents in chronic undifferentiated spondylarthritis.

Please wait, while we are loading the content...

Cartilage repair in a rat model of osteoarthritis through intraarticular transplantation of muscle-derived stem cells expressing bone morphogenetic protein 4 and soluble Flt-1.

Regulation of autophagy in human and murine cartilage: hypoxia-inducible factor 2 suppresses chondrocyte autophagy.

Induction of CCR2-dependent macrophage accumulation by oxidized phospholipids in the air-pouch model of inflammation.

Chlamydiae as etiologic agents in chronic undifferentiated spondylarthritis.

Clinical images: Cement embolism following percutaneous vertebroplasty.

Association of interleukin-1 receptor antagonist and interleukin-6 polymorphisms with osteolysis after total hip arthroplasty: comment on the article by Gordon et al.

The PRL -1149 G/T polymorphism and rheumatoid arthritis susceptibility.

Premature atherosclerosis in pediatric systemic lupus erythematosus: risk factors for increased carotid intima-media thickness in the atherosclerosis prevention in pediatric lupus erythematosus cohort.

Regulation of pulmonary inflammation and fibrosis through expression of integrins alphaVbeta3 and alphaVbeta5 on pulmonary T lymphocytes.

Down-regulation of myeloid cell leukemia 1 by epigallocatechin-3-gallate sensitizes rheumatoid arthritis synovial fibroblasts to tumor necrosis factor alpha-induced apoptosis.

Gene expression profiling in neutrophils from children with polyarticular juvenile idiopathic arthritis.

Cadherin 11 promotes invasive behavior of fibroblast-like synoviocytes.

The dynamics of macrophage lineage populations in inflammatory and autoimmune diseases.

Should patients with rheumatoid arthritis receive statin therapy?

Effect of ciprofloxacin-mediated inhibition on cell proliferation in rat tendon cells: Comment on the article.

Clinical images: Podoconiosis: foot edema resulting from regional geochemistry.

Clinical images: Gout attack and stiff knee in an airline passenger in economy class.

Mann-Whitney U test and Kruskal-Wallis test should be used for comparisons of differences in medians, not means: comment on the article by van der Helm-van Mil et al.

Year: 2009 Volume: 60 Issue: 4

Year: 2009 Volume: 60 Issue: 3

Year: 2009 Volume: 60 Issue: 2

Year: 2009 Volume: 60 Issue: 1

Year: 2008 Volume: 59

Year: 2008 Volume: 58

Year: 2007 Volume: 57

Year: 2007 Volume: 56

Year: 2006 Volume: 55

Year: 2006 Volume: 54

Year: 2005 Volume: 53

Year: 2005 Volume: 52

Year: 2004 Volume: 51

Year: 2004 Volume: 50

Year: 2003 Volume: 48

Year: 2002 Volume: 46

Year: 2001 Volume: 44

Year: 2000 Volume: 43

Chlamydiae as etiologic agents in chronic undifferentiated spondylarthritis.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Carter, John D. Gérard, Hervé C. Espinoza, Luis R. Ricca, Louis R. Valeriano, Joanne Snelgrove, Jessica Oszust, Cynthia Vasey, Frank B. Hudson, Alan P.
Description	Country affiliation: United States Author Affiliation: Carter JD ( University of South Florida College of Medicine, Tampa, FL 33612, USA. jocarter@health.usf.edu)
Abstract	OBJECTIVE: The majority of patients with Chlamydia-induced reactive arthritis do not present with the classic triad of arthritis, conjunctivitis/iritis, and urethritis. Moreover, acute chlamydial infections are often asymptomatic. The aim of the present study was to assess the prevalence of synovial Chlamydia trachomatis and Chlamydia pneumoniae infections in patients with chronic undifferentiated spondylarthritis (uSpA). METHODS: Study patients met the European Spondylarthropathy Study Group criteria for SpA, without evidence of ankylosing spondylitis, psoriasis, inflammatory bowel disease, or preceding dysentery. Symptoms were present for >or=6 months. Each patient underwent a synovial biopsy; tissue and concomitantly obtained peripheral blood mononuclear cells (PBMCs) were analyzed by polymerase chain reaction (PCR) for C trachomatis and C pneumoniae DNA. Other data collected on the day of the biopsy included standard demographic information and medical history, including any known history of C trachomatis or C pneumoniae. Physical examination (including joint count, evaluation for dactylitis and/or enthesitis, and skin examination) and HLA-B27 typing were performed. Synovial tissue (ST) samples from 167 patients with osteoarthritis (OA) were used as controls. RESULTS: Twenty-six patients met the entry criteria and underwent synovial biopsy (25 knee, 1 wrist). Sixteen of them (62%) were positive for C trachomatis and/or C pneumoniae DNA (10 for C trachomatis, 4 for C pneumoniae, and 2 for both). PCR analysis of ST revealed the presence of Chlamydia significantly more frequently in patients with uSpA than in OA controls (P<0.0001). No specific clinical characteristics differentiated Chlamydia-positive from Chlamydia-negative patients. PBMCs from 4 of the 26 uSpA patients (15%) were positive for Chlamydia, and Chlamydia was found in ST from 2 of these 4 patients. No significant correlation between PCR positivity and HLA-B27 positivity was found. CONCLUSION: The frequency of Chlamydia-positive ST samples, as determined by PCR, was found to be significantly higher in patients with uSpA than in patients with OA. Our results suggest that in many patients with uSpA, chlamydial infection, which is often occult, may be the cause.
File Format	HTM / HTML
ISSN	00043591
e-ISSN	15290131
DOI	10.1002/art.24431
Journal	Arthritis & Rheumatism
Issue Number	5
Volume Number	60
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2009-05-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Research Support, N.i.h., Extramural Chlamydia Trachomatis Microbiology Complications Hla-b27 Antigen Chlamydophila Infections Chlamydophila Pneumoniae Dna, Bacterial Chlamydia Infections Spondylarthritis Polymerase Chain Reaction Synovial Membrane Chronic Disease Osteoarthritis Discipline Rheumatic Diseases
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology Pharmacology (medical) Rheumatology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Persistent Chlamydiae and chronic arthritis

Patients with Chlamydia-associated arthritis have ocular (trachoma), not genital, serovars of C. trachomatis in synovial tissue.

No evidence of Chlamydia pneumoniae in the synovia of patients with osteoarthritis

Chlamydiae as pathogens: new species and new issues.

Detection of Chlamydia trachomatis-DNA in synovial fluid: evaluation of the sensitivity of different DNA extraction methods and amplification systems

Initial characterization of Chlamydophila (Chlamydia) pneumoniae cultured from the late-onset Alzheimer brain.

Integrin 4ß1 is necessary for CD4+ T cell-mediated protection against genital Chlamydia trachomatis infection.

Reaktive Arthritis: Von der Pathogenese zu neuen Therapiekonzepten.

Chlamydiae as Etiologic Agents for Chronic Undifferentiated Spondyloarthritis

Chlamydiae as etiologic agents in chronic undifferentiated spondylarthritis.

Similar Documents

Persistent Chlamydiae and chronic arthritis

Patients with Chlamydia-associated arthritis have ocular (trachoma), not genital, serovars of C. trachomatis in synovial tissue.

No evidence of Chlamydia pneumoniae in the synovia of patients with osteoarthritis

Chlamydiae as pathogens: new species and new issues.

Detection of Chlamydia trachomatis-DNA in synovial fluid: evaluation of the sensitivity of different DNA extraction methods and amplification systems

Initial characterization of Chlamydophila (Chlamydia) pneumoniae cultured from the late-onset Alzheimer brain.

Integrin 4ß1 is necessary for CD4+ T cell-mediated protection against genital Chlamydia trachomatis infection.

Reaktive Arthritis: Von der Pathogenese zu neuen Therapiekonzepten.

Chlamydiae as Etiologic Agents for Chronic Undifferentiated Spondyloarthritis

Chlamydiae as etiologic agents in chronic undifferentiated spondylarthritis.