NDLI: Live attenuated nephropathogenic infectious bronchitis virus vaccine provides broad cross protection against new variant strains

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Lim, T-H Kim, M-S Jang, J-H Lee, D-H Park, J-K Youn, H-N Lee, J-B Park, S-Y Choi, I-S Song, C-S
Spatial Coverage	Republic of Korea
Description	Author Affiliation: Lim TH ( College of Veterinary Medicine, Konkuk University, 1 Hwayang-dong, Gwangjin-gu, Seoul, 143-701, Korea.)
Abstract	Infectious bronchitis virus (IBV) infections cause great economic losses to the poultry industry worldwide, and the emergence of new variant strains complicates disease control. The present study investigated the genetic and protectotypic features of newly emerged Korean IBV strains. A phylogenetic analysis showed that several recent isolates formed 2 different clusters (new cluster 1 and 2), which were distinct from other preexisting clusters. New cluster 1 IBV strains represented recombinants between Korean nephropathogenic strain KM91 and the QXIBV strain. New cluster 2 IBV strains showed low amino acid homology (<58.7%) compared with previous isolates. We evaluated the protective efficacy of commercial IBV vaccines (H120 and K2 strain) against these new isolates. In cross-protection studies, the H120 strain did not provide sufficient protection against these variants. However, highly attenuated nephropathogenic IBV vaccine, K2 strain, provided significantly higher levels of protection against variants compared with chickens vaccinated with H120 (P < 0.05 or better). These results indicate that the K2 vaccine could be helpful for the reduction of economic losses caused by newly evolving IBV recombinants (new cluster 1) and variants (new cluster 2).
File Format	HTM / HTML
ISSN	00325791
e-ISSN	15253171
Journal	Poultry Science
Issue Number	1
Volume Number	91
Language	English
Publisher	Oxford University Press
Publisher Date	2012-01-01
Publisher Place	Great Britain (UK)
Access Restriction	Open
Subject Keyword	Discipline Veterinary Medicine Coronavirus Infections Veterinary Cross Protection Infectious Bronchitis Virus Membrane Glycoproteins Genetics Poultry Diseases Prevention & Control Viral Envelope Proteins Viral Vaccines Immunology Animals Chick Embryo Classification Kidney Pathology Virology Molecular Sequence Data Phylogeny Rna, Viral Reverse Transcriptase Polymerase Chain Reaction Sequence Analysis, Dna Specific Pathogen-free Organisms Spike Glycoprotein, Coronavirus Trachea Vaccines, Attenuated Adverse Effects Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Medicine Animal Science and Zoology

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