NDLI: Preclinical evaluation of strontium-containing bioactive bone cement.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Li, Zhaoyang Yuan, Ning Lam, Raymond Wing Moon Cui, Zhenduo Yang, Xianjin Lu, William Weijia
Description	Author Affiliation: Li Z ( School of Materials Science and Engineering, Tianjin University, Tianjin 300072, China)
Abstract	Strontium (Sr) has become more attractive for orthopaedic applications as they can simultaneously stimulate bone formation and prevent bone loss. A Sr-containing bioactive bone cement (Sr-BC) has been designed to fix osteoporotic bone fracture. Sr is a trace element, so the safety of containing Sr is concerned when Sr-BC is implanted in human body. The preclinical assessment of biocompatibility of Sr-BC was conducted according to ISO 10993 standards. MTT assay showed that this bioactive bone cement was non-toxic to mouse fibroblasts, and it met the basic requirement for the orthopaedic implant. The three independent genetic toxicity studies including Ames, chromosome aberration and bone marrow micronucleus assays demonstrated absence of genotoxic components in Sr-BC, which reassured the safety concerns of this novel bone cement. The muscle implantation results in present study were also encouraging. The acute inflammation around the cement was observed at 1 week post-implantation; however, no significant difference was observed between control and Sr-BC groups. These responses may be attributed to the presence of the foreign body, but the tissue healed after 12 weeks implantation. In summary, the above preclinical results provide additional assurance for the safety of this implant. Sr-BC can be used as a potential alternative to the traditional bone cement.
File Format	HTM / HTML
ISSN	09284931
Issue Number	8
Volume Number	33
e-ISSN	18730191
Journal	Materials Science and Engineering: C
Language	English
Publisher	Elsevier
Publisher Date	2013-12-01
Publisher Place	Netherlands
Access Restriction	Subscribed
Subject Keyword	Discipline Materials Science Bone Cements Chemistry Strontium Animals Toxicity Cell Line Cell Survival Drug Effects Chromosome Aberrations Cricetinae Fibroblasts Cytology Metabolism Materials Testing Mice Muscle, Skeletal Physiology Prostheses And Implants Rabbits Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Mechanics of Materials Biomaterials Condensed Matter Physics Bioengineering Mechanical Engineering

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