NDLI: Characterization of thermoplastic polyurethane/polylactic acid (TPU/PLA) tissue engineering scaffolds fabricated by microcellular injection molding.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Mi, Hao-Yang Salick, Max R. Jing, Xin Jacques, Brianna R. Crone, Wendy C. Peng, Xiang-Fang Turng, Lih-Sheng
Description	Country affiliation: United States Author Affiliation: Mi HY ( National Engineering Research Center of Novel Equipment for Polymer Processing, South China University of Technology, Guangzhou, China)
Abstract	Polylactic acid (PLA) and thermoplastic polyurethane (TPU) are two kinds of biocompatible and biodegradable polymers that can be used in biomedical applications. PLA has rigid mechanical properties while TPU possesses flexible mechanical properties. Blended TPU/PLA tissue engineering scaffolds at different ratios for tunable properties were fabricated via twin screw extrusion and microcellular injection molding techniques for the first time. Multiple test methods were used to characterize these materials. Fourier transform infrared spectroscopy (FTIR) confirmed the existence of the two components in the blends; differential scanning calorimetry (DSC) and dynamic mechanical analysis (DMA) confirmed the immiscibility between the TPU and PLA. Scanning electron microscopy (SEM) images verified that, at the composition ratios studied, PLA was dispersed as spheres or islands inside the TPU matrix and that this phase morphology further influenced the scaffold's microstructure and surface roughness. The blends exhibited a large range of mechanical properties that covered several human tissue requirements. 3T3 fibroblast cell culture showed that the scaffolds supported cell proliferation and migration properly. Most importantly, this study demonstrated the feasibility of mass producing biocompatible PLA/TPU scaffolds with tunable microstructures, surface roughnesses, and mechanical properties that have the potential to be used as artificial scaffolds in multiple tissue engineering applications.
File Format	HTM / HTML
ISSN	09284931
e-ISSN	18730191
DOI	10.1016/j.msec.2013.07.037
Journal	Materials Science and Engineering: C
Issue Number	8
Volume Number	33
Language	English
Publisher	Elsevier
Publisher Date	2013-12-01
Publisher Place	Netherlands
Access Restriction	Open
Subject Keyword	Discipline Materials Science Biocompatible Materials Chemistry Lactic Acid Polymers Polyurethanes Tissue Scaffolds Animals Pharmacology Cell Movement Drug Effects Cell Proliferation Mice Nih 3t3 Cells Polyesters Rheology Tensile Strength Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Mechanics of Materials Biomaterials Condensed Matter Physics Bioengineering Mechanical Engineering

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