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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Géczy, Tamás Oláh, Attila Tóth, Balázs I. Czifra, Gabriella Szöllosi, Attila G. Szabó, Tamás Zouboulis, Christos C. Paus, Ralf Bíró, Tamás |
| Description | Country affiliation: Hungary Author Affiliation: Géczy T ( DE-MTA Lendület Cellular Physiology Research Group, Department of Physiology, Research Center for Molecular Medicine, University of Debrecen, Debrecen, Hungary.) |
| Abstract | Protein kinase C (PKC) isoforms have crucial roles in cutaneous signaling. Interestingly, we lack information about their involvement in human sebaceous gland biology. Therefore, in this current study, we investigated the functions of the PKC system in human immortalized SZ95 sebocytes. Using molecular biological approaches, imaging, and functional assays, we report that SZ95 sebocytes express the conventional cPKC ; the novel nPKCδ, É, and η; and the atypical aPKCζ. Activation of the PKC system by phorbol 12-myristate 13-acetate (PMA) stimulated lipid synthesis (a hallmark of differentiation) and resulted in translocation and then downregulation of cPKC and nPKCδ. In good accord with these findings, the effect of PMA was effectively abrogated by inhibitors and short interfering RNA-mediated 'silencing' of cPKC and nPKCδ. Of further importance, molecular or pharmacological inhibition of nPKCδ also prevented the lipogenic and apoptosis-promoting action of arachidonic acid. Finally, we also found that 'knockdown' of the endogenous aPKCζ activity markedly increased basal lipid synthesis and apoptosis, suggesting its constitutive activity in suppressing these processes. Collectively, our findings strongly argue for the fact that certain PKCs have pivotal, isoform-specific, differential, and antagonistic roles in the regulation of human sebaceous gland-derived sebocyte biology. |
| File Format | HTM / HTML |
| ISSN | 0022202X |
| e-ISSN | 15231747 |
| Journal | Journal of Investigative Dermatology |
| Issue Number | 8 |
| Volume Number | 132 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2012-08-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Discipline Dermatology Gene Expression Regulation, Enzymologic Protein Kinase C-alpha Biosynthesis Protein Kinase C-delta Protein Kinase C-epsilon Protein Kinase C Sebaceous Glands Cytology Apoptosis Cell Differentiation Down-regulation Gene Silencing Lipids Chemistry Necrosis Protein Isoforms Rna, Small Interfering Metabolism Tetradecanoylphorbol Acetate Pharmacology Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Biochemistry Molecular Biology Dermatology |
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