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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Liu, Yuan Zhu, Kui Wang, Jianfen Huang, Xiaoyong Wang, Guanlin Li, Congying Cao, Jie Ding, Shuangyang |
| Description | Country affiliation: China Author Affiliation: Liu Y ( National Reference Laboratory for Veterinary Drug Residues, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.); Zhu K ( Department of Biomedical Engineering, Duke University, Durham, 27708 NC, USA.); Wang J ( Animal Husbandry Technology Promotion Station, Yanqing County, Beijing 102100, China.); Huang X ( National Reference Laboratory for Veterinary Drug Residues, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.); Wang G ( National Reference Laboratory for Veterinary Drug Residues, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.); Li C ( National Reference Laboratory for Veterinary Drug Residues, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.); Cao J ( National Reference Laboratory for Veterinary Drug Residues, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China. Electronic address: caojie010@163.com.); Ding S ( National Reference Laboratory for Veterinary Drug Residues, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China. Electronic address: ding_sy@126.com.) |
| Abstract | Amoxicillin (AMOX), clavulanic acid (CLAV) and prednisolone (PSL) are widely used in combination for the treatment of mastitis in lactating dairy cows. However, no method has been reported to detect these three chemicals in milk in a single assay. In the present work, a reliable and sensitive UPLC-MS/MS method was developed and validated for simultaneous determination of AMOX, CLAV and PSL in cow's milk. The analytes were determined by a positive and negative ionization electrospray mass spectrometer via multiple reaction monitoring. The linear ranges of AMOX, CLAV and PSL were from 2 to 1000ng/mL, 20-1000ng/mL and 1-1000ng/mL, respectively, with the correlation coefficients greater than 0.999. The limits of quantification (LOQs) were 2ng/mL (AMOX), 20ng/mL (CLAV) and 1ng/mL (PSL). Recoveries of the analytes of interest in milk samples were in the ranges of 84.2-101.4%. The intra-day and inter-day precisions ranged from 1.8% to 11.9%. This method was successfully applied to investigate the pharmacokinetics of AMOX, CLAV and PSL in milk from healthy and mastitic cows. The elimination times of AMOX and PSL in mastitic cows were longer than that in healthy cows, but the elimination times of CLAV did not show significant difference. |
| File Format | HTM / HTML |
| ISSN | 15700232 |
| Volume Number | 1008 |
| e-ISSN | 1873376X |
| Journal | Journal of Chromatography B |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2016-01-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Analytical Chemistry Amoxicillin Pharmacokinetics Chromatography, Liquid Methods Clavulanic Acid Milk Chemistry Prednisolone Tandem Mass Spectrometry Animals Cattle Female Limit Of Detection Reproducibility Of Results Comparative Study Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Medicine Analytical Chemistry Clinical Biochemistry Biochemistry |
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