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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Gika, Helen G. Zisi, Chrysostomi Theodoridis, Georgios Wilson, Ian D. |
| Description | Author Affiliation: Gika HG ( School of Chemical Engineering, Aristotle University, Thessaloniki 54124, Greece. Electronic address: gkikae@auth.gr.); Zisi C ( Department of Chemistry, Aristotle University of Thessaloniki, 54124 Greece.); Theodoridis G ( Department of Chemistry, Aristotle University of Thessaloniki, 54124 Greece.); Wilson ID ( Department of Surgery and Cancer, Imperial College, Exhibition Rd., South Kensington, London SW7 2AZ, UK.) |
| Abstract | The process of untargeted metabolic profiling/phenotyping of complex biological matrices, i.e., biological fluids such as blood plasma/serum, saliva, bile, and tissue extracts, provides the analyst with a wide range of challenges. Not the least of these challenges is demonstrating that the acquired data are of 'good' quality and provide the basis for more detailed multivariate, and other, statistical analysis necessary to detect, and identify, potential biomarkers that might provide insight into the process under study. Here straightforward and pragmatic 'quality control (QC)' procedures are described that allow investigators to monitor the analytical processes employed for global, untargeted, metabolic profiling. The use of this methodology is illustrated with an example from the analysis of human urine where an excel spreadsheet of the preprocessed LC-MS output is provided with embedded macros, calculations and visualization plots that can be used to explore the data. Whilst the use of these procedures is exemplified on human urine samples, this protocol is generally applicable to metabonomic/metabolomic profiling of biofluids, tissue and cell extracts from many sources. |
| File Format | HTM / HTML |
| ISSN | 15700232 |
| Journal | Journal of Chromatography B |
| Volume Number | 1008 |
| e-ISSN | 1873376X |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2016-01-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Analytical Chemistry Body Fluids Metabolism Chromatography, High Pressure Liquid Methods Mass Spectrometry Quality Control Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Medicine Analytical Chemistry Clinical Biochemistry Biochemistry |
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