NDLI: Identification and characterization of $Cs^{+}-permeable$ $K^{+}$ channel current in mouse cerebellar Purkinje cells in lobules 9 and 10 evoked by molecular layer stimulation

Please wait, while we are loading the content...

Year: 2017 Volume: 45

Year: 2016 Volume: 44

Year: 2016 Volume: 43

Year: 2015 Volume: 42

Year: 2015 Volume: 41

Year: 2014 Volume: 40

Year: 2014 Volume: 39

Year: 2013 Volume: 38

Year: 2013 Volume: 37

Year: 2012 Volume: 36

Year: 2012 Volume: 35

Year: 2011 Volume: 34

Year: 2011 Volume: 33

Year: 2010 Volume: 32

Year: 2010 Volume: 32 Issue: 12

Year: 2010 Volume: 32 Issue: 11

Year: 2010 Volume: 32 Issue: 10

Year: 2010 Volume: 32 Issue: 9

Year: 2010 Volume: 32 Issue: 8

Year: 2010 Volume: 32 Issue: 7

Year: 2010 Volume: 32 Issue: 6

Year: 2010 Volume: 32 Issue: 5

Neural correlates of the orthographic neighborhood size effect in Chinese.

Early change detection in humans as revealed by auditory brainstem and middle-latency evoked potentials.

Effects of urethane anaesthesia on sensory processing in the rat barrel cortex revealed by combined optical imaging and electrophysiology.

Long-lasting modulation of synaptic plasticity in rat hippocampus after early-life complex febrile seizures.

Effects of albumin-conjugated PYY on food intake: the respective roles of the circumventricular organs and vagus nerve.

Exposure to a novel context following contextual fear conditioning enhances the induction of hippocampal long-term potentiation.

Functional identification of an outwardly rectifying pH- and anesthetic-sensitive leak $K^{+}$ conductance in hippocampal astrocytes

Signaling through erbB receptors is a critical functional regulator in the mature cochlea.

Identification and characterization of $Cs^{+}-permeable$ $K^{+}$ channel current in mouse cerebellar Purkinje cells in lobules 9 and 10 evoked by molecular layer stimulation

Dissociating the role of the caudate nucleus and dorsolateral prefrontal cortex in the monitoring of events within human working memory.

Impairment of CaMKII activation and attenuation of neuropathic pain in mice lacking NR2B phosphorylated at Tyr1472

Phenotypic and genetic analysis of the cerebellar mutant tmgc26, a new ENU-induced ROR-alpha allele.

Heterogeneity of the supramammillary-hippocampal pathways: evidence for a unique GABAergic neurotransmitter phenotype and regional differences.

Eccentric exercise induces chronic alterations in musculoskeletal nociception in the rat.

Cortical cholinergic abnormalities contribute to the amnesic state induced by pyrithiamine-induced thiamine deficiency in the rat.

Alcohol consumption enhances antiretroviral painful peripheral neuropathy by mitochondrial mechanisms.

Levels of DNAJB family members (HSP40) correlate with disease onset in patients with spinocerebellar ataxia type 3

Requirement of cannabinoid $CB_{1}$ receptor in cortical pyramidal neurons for appropriate development of corticothalamic and thalamocortical projections

Year: 2010 Volume: 32 Issue: 4

Year: 2010 Volume: 32 Issue: 3

Year: 2010 Volume: 32 Issue: 2

Year: 2010 Volume: 32 Issue: 1

Year: 2010 Volume: 31

Year: 2009 Volume: 30

Year: 2009 Volume: 29

Year: 2008 Volume: 28

Year: 2008 Volume: 27

Year: 2007 Volume: 26

Identification and characterization of $Cs^{+}-permeable$ $K^{+}$ channel current in mouse cerebellar Purkinje cells in lobules 9 and 10 evoked by molecular layer stimulation

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Ishii, Hiroshi Nakajo, Koichi Yanagawa, Yuchio Kubo, Yoshihiro
Description	Country affiliation: Japan Author Affiliation: Ishii H ( Division of Biophysics and Neurobiology, Department of Molecular Physiology, National Institute for Physiological Sciences, Okazaki, Aichi, Japan.)
Abstract	The mouse cerebellum consists of 10 lobules, which are distinguishable by their anatomical and functional properties. However, the differences in the slow postsynaptic currents (sPSCs) of Purkinje cells between lobules have not been well studied. We recorded the sPSCs of lobules 3, 9 and 10 evoked by tetanic stimulation of the molecular layer in cerebellar slices, and found a novel outward sPSC mediated by the $GABA_{B}$ receptor in loblues 9 and 10 but hardly at all in lobule 3. We showed that the lobule-specific difference is at least partly attributable to differences in the density of GABAergic neurons (higher in lobule 10 than in lobules 3 and 9), and the functional expression level of postsynaptic $GABA_{B}$ receptor currents (larger in lobules 9 and 10 than in lobule 3). The G-protein-coupled inward rectifying $K^{+}$ channel (GIRK) is known to be activated by $GABA_{B}$ receptors; however, the outward sPSC was not blocked by a GIRK blocker, was not sensitive to $Cs^{+}$ block, and was observed when $Cs^{+}$ was used as a charge carrier. These results suggest that a $K^{+}$ channel other than GIRK could be activated by $GABA_{B}$ receptors. KCNK13 is a $Cs^{+}-permeable$ $K^{+}$ channel that shows intense expression of mRNA in Purkinje cells. KCNK13 current was enhanced by co-expression of $G_{βγ}$ subunits and was observed when $Cs^{+}$ was used as a charge carrier in heterologous expression systems, and the amino acids critical for these features were identified by mutagenesis. Taken together, these results show that KCNK13 is a legitimate candidate for the $Cs^{+}-permeable$ $K^{+}$ channel activated by $GABA_{B}$ receptors, presumably via $G_{βγ}$ subunits in Purkinje cells.
File Format	HTM / HTML
ISSN	0953816X
Issue Number	5
Volume Number	32
e-ISSN	14609568
Journal	European Journal of Neuroscience
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2010-09-01
Publisher Place	France
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Neuroscience Cerebellum Physiology Cesium Purkinje Cells Synaptic Potentials Animals Cho Cells Cell Culture Techniques Cell Line, Transformed Anatomy & Histology Drug Effects Metabolism Antagonists & Inhibitors Cricetinae Cricetulus Electric Stimulation Methods G Protein-coupled Inwardly-rectifying Potassium Channels Gaba-b Receptor Antagonists Pharmacology Mice Mice, Inbred C57bl Oocytes Phosphinic Acids Potassium Channel Blockers Potassium Channels, Tandem Pore Domain Genetics Propanolamines Receptors, Gaba-b Xenopus Journal Article
Content Type	Text
Resource Type	Article
Subject	Neuroscience

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in