NDLI: Long-lasting modulation of synaptic plasticity in rat hippocampus after early-life complex febrile seizures.

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Long-lasting modulation of synaptic plasticity in rat hippocampus after early-life complex febrile seizures.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Notenboom, Robbert G. E. Ramakers, Geert M. J. Kamal, Amer Spruijt, Berry M. de Graan, Pierre N. E.
Description	Country affiliation: Netherlands Author Affiliation: Notenboom RG ( Rudolf Magnus Institute of Neuroscience, Department of Neuroscience & Pharmacology, University Medical Center Utrecht, Utrecht, The Netherlands. r.g.e.notenboom@lumc.nl)
Abstract	A small fraction of children with febrile seizures appears to develop cognitive impairments. Recent studies in a rat model of hyperthermia-induced febrile seizures indicate that prolonged febrile seizures early in life have long-lasting effects on the hippocampus and induce cognitive deficits. However, data on network plasticity and the nature of cognitive deficits are conflicting. We examined three specific measures of hippocampal plasticity in adult rats with a prior history of experimental febrile seizures: (i) activity-dependent synaptic plasticity (long-term potentiation and depression) by electrophysiological recordings of Schaffer collateral/commissural-evoked field excitatory synaptic potentials in CA1 of acute hippocampal slices; (ii) Morris water maze spatial learning and memory; and (iii) hippocampal mossy fiber plasticity by Timm histochemistry and quantification of terminal sprouting in CA3 and the dentate gyrus. We found enhanced hippocampal CA1 long-term potentiation and reduced long-term depression but normal spatial learning and memory in adult rats that were subjected to experimental febrile seizures on postnatal day 10. Furthermore, rats with experimental febrile seizures showed modest but significant sprouting of mossy fiber collaterals into the inner molecular layer of the dentate gyrus in adulthood. We conclude that enhanced CA1 long-term potentiation and mild mossy fiber sprouting occur after experimental febrile seizures, without affecting spatial learning and memory in the Morris water maze. These long-term functional and structural alterations in hippocampal plasticity are likely to play a role in the enhanced seizure susceptibility in this model of prolonged human febrile seizures but do not correlate with overt cognitive deficits.
File Format	HTM / HTML
ISSN	0953816X
Issue Number	5
Volume Number	32
e-ISSN	14609568
Journal	European Journal of Neuroscience
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2010-09-01
Publisher Place	France
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Neuroscience Ca1 Region, Hippocampal Physiopathology Mossy Fibers, Hippocampal Pathology Neuronal Plasticity Physiology Seizures, Febrile Synaptic Transmission Animals Animals, Newborn Disease Models, Animal Hyperthermia, Induced Male Maze Learning Rats Rats, Sprague-dawley Journal Article
Content Type	Text
Resource Type	Article
Subject	Neuroscience

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