NDLI: Signaling through erbB receptors is a critical functional regulator in the mature cochlea.

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Signaling through erbB receptors is a critical functional regulator in the mature cochlea.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Watanabe, Futoshi Kirkegaard, Mette Matsumoto, Suguru Gont, Cecilia Mannström, Paula Ulfendahl, Mats Fridberger, Anders
Description	Country affiliation: Sweden Author Affiliation: Watanabe F ( Center for Hearing and Communication Research and Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.)
Abstract	Noise, ototoxic substances and various genetic factors are common causes of profound hearing loss. Cochlear implants can often restore hearing in these cases, but only if a sufficient number of responsive auditory nerve fibers remain. Over time, these nerve fibers degenerate in the damaged ear, and it is therefore important to establish factors that control neuronal survival and maintain neural excitability. Recent studies show that neuregulins and their receptors are important for survival and proper targeting of neurons in the developing inner ear. A role for neuregulins as maintainers of the neuronal population in the mature inner ear was therefore hypothesized. Here, this hypothesis was directly tested by chronic local application of substances that block neuregulin receptors. Using auditory brainstem response measurements, we demonstrate that such receptor block leads to a progressive hearing impairment that develops over the course of weeks. This impairment occurs despite a normal number of auditory neurons and preserved outer hair cell function. Real-time quantitative reverse transcriptase-polymerase chain reaction shows alterations in neurotrophin-3 expression, suggesting that this growth factor participates in regulating cochlear sensitivity. The present work demonstrates the critical importance of neuregulin/erbB signaling in long-term functional regulation in the mature guinea pig hearing organ.
File Format	HTM / HTML
ISSN	0953816X
Issue Number	5
Volume Number	32
e-ISSN	14609568
Journal	European Journal of Neuroscience
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2010-09-01
Publisher Place	France
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Neuroscience Cochlea Physiology Evoked Potentials, Auditory, Brain Stem Hair Cells, Auditory, Outer Receptor Protein-tyrosine Kinases Animals Cell Count Methods Drug Effects Metabolism Female Gene Expression Guinea Pigs Microinjections Neurotrophin 3 Quinazolines Pharmacology Antagonists & Inhibitors Receptors, Glutamate Spiral Ganglion Anatomy & Histology Time Factors Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Neuroscience

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Signaling through erbB receptors is a critical functional regulator in the mature cochlea.

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Signaling through erbB receptors is a critical functional regulator in the mature cochlea.