NDLI: Effects of albumin-conjugated PYY on food intake: the respective roles of the circumventricular organs and vagus nerve.

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Effects of albumin-conjugated PYY on food intake: the respective roles of the circumventricular organs and vagus nerve.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Baraboi, Elena-Dana Michel, Chantal Smith, Pauline Thibaudeau, Karen Ferguson, Alastair V. Richard, Denis
Description	Country affiliation: Canada Author Affiliation: Baraboi ED ( Merck-Frosst/CIHR Research Chair in Obesity and Institut universitaire de cardiologie et de pneumologie de Québec, 2725 Chemin Sainte-Foy, QC, Canada.)
Abstract	The mechanism and routes through which peptide tyrosine-tyrosine (PYY) exerts its anorectic effects are still largely unknown. In the present study, we investigated the roles of the area postrema (AP), subfornical organ (SFO) and vagus nerve in mediating the anorectic effect of PYY using PYY(3-36) conjugated to human serum albumin (PYY(3-36)-HSA) in rats. PYY(3-36)-HSA is a large molecule that does not penetrate the blood-brain barrier, and thus provides a useful tool to discriminate between the central (brain) and peripheral actions of this peptide. PYY(3-36)-HSA induced significant reductions in food and body weight gain up to 24 h after administration. The anorectic effect of PYY(3-36)-HSA was delayed for 2 h in rats in which both AP and SFO were ablated, while lesion of either of these circumventricular organs in isolation did not influence the feeding responses to PYY(3-36)-HSA. The PYY(3-36)-HSA-induced anorectic effect was also reduced during the 3- to 6-h period following subdiaphragmatic vagotomy. Lesions of AP, SFO and AP/SFO as well as subdiaphragmatic vagotomy blunted PYY(3-36)-HSA-induced expression of c-fos mRNA in specific brain structures including the bed nucleus of stria terminalis, central amygdala, lateral-external parabrachial nucleus and medial nucleus of the solitary tract. In addition, subdiaphragmatic vagotomy inhibited the neuronal activation induced by PYY(3-36)-HSA in AP and SFO. These findings suggest that the anorectic effect and brain neuronal activation induced by PYY(3-36)-HSA are dependent on integrity of AP, SFO and subdiaphragmatic vagus nerve.
File Format	HTM / HTML
ISSN	0953816X
Issue Number	5
Volume Number	32
e-ISSN	14609568
Journal	European Journal of Neuroscience
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2010-09-01
Publisher Place	France
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Neuroscience Appetite Depressants Pharmacology Appetite Regulation Physiology Eating Peptide Yy Serum Albumin Subfornical Organ Animals Drug Effects Area Postrema Blood Glucose Body Weight Brain Drinking Humans Insulin Blood Male Neurons Peptide Fragments Chemistry Rats Rats, Wistar Vagotomy Methods Vagus Nerve Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Neuroscience

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