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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Yang, Bo Lu, Changlin Wu, Qing Zhang, Jian Zhao, Hua Cao, Yukang |
| Description | Author Affiliation: Yang B ( Department of Cardiology, Chinese PLA General Hospital, Beijing 100853, China. Electronic address: dryangb@aliyun.com.); Lu C ( Department of Cardiology, Beijing Chaoyang Hospital affiliated to Capital Medical University, Beijing 100020, China. Electronic address: liuchanglinbeij@sina.com.); Wu Q ( Department of Cardiology, Chinese PLA General Hospital, Beijing 100853, China.); Zhang J ( Department of Cardiology, Chinese PLA General Hospital, Beijing 100853, China.); Zhao H ( Department of Cardiology, Chinese PLA General Hospital, Beijing 100853, China.); Cao Y ( Department of Cardiology, Chinese PLA General Hospital, Beijing 100853, China.) |
| Abstract | BACKGROUND: Inconsistent findings have reported on parathyroid hormone (PTH) concentration and cardiovascular or all-cause mortality. OBJECTIVE: To investigate whether elevated PTH concentration was an independent predictor for cardiovascular or all-cause mortality in the general population by conducting a meta-analysis based on prospective studies. METHOD: We searched Cochrane Library, Pubmed, and Embase databases up to June 2015. Only prospective studies evaluating serum PTH concentration and cardiovascular or all-cause mortality were included. Pooled adjust risk ratio (RR) and corresponding 95% confidence intervals (CI) were calculated for the highest vs. lowest PTH concentration. RESULTS: Ten studies with 31,616 subjects were identified and analyzed. Compared the highest to the lowest PTH concentration, elevated serum PTH concentration increased the risk of all-cause mortality (RR 1.19; 95% CI 1.08-1.30) but not for cardiovascular mortality (RR 1.26; 95% CI 0.96-1.66). Subgroup analyses indicated that cardiovascular mortality risk appeared to be more pronounced among men (RR 1.68; 95% CI 1.05-2.67). CONCLUSIONS: Elevated PTH concentration is an independent predictor of all-cause mortality. Elevated serum PTH concentration appears to increase risk of cardiovascular mortality among men. |
| File Format | HTM / HTML |
| ISSN | 00098981 |
| Journal | Clinica Chimica Acta |
| Volume Number | 455 |
| e-ISSN | 18733492 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2016-04-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biochemistry (medical) Clinical Biochemistry Biochemistry |
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