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| Content Provider | Springer Nature Link |
|---|---|
| Author | Peng, Hui yong Man, Chang feng Xu, Juan Fan, Yu |
| Copyright Year | 2015 |
| Abstract | To investigate whether elevated homocysteine levels were a predictor of subsequent coronary heart disease (CHD) mortality, cardiovascular mortality or all-cause mortality in the general population by a metaanalysis.In a systematic search conducted in the databases of PubMed and Embase prior to October 2013, we identified relevant prospective observational studies evaluating the association between baseline homocysteine levels and CHD mortality, cardiovascular or all-cause mortality in the general population. Pooled adjust risk ratio (RR) and corresponding 95% confidence interval (CI) were calculated separately for categorical risk estimates and continuous risk estimates.Twelve studies with 23 623 subjects were included in the meta-analysis. Comparing the highest to lowest homocysteine level categories, CHD mortality increased by 66% (RR 1.66; 95% CI 1.12–2.47; P=0.012), cardiovascular mortality increased by 68% (RR 1.68; 95% CI 1.04–2.70; P=0.033), and all-cause mortality increased by 93% (RR 1.93; 95% CI 1.54–2.43; P<0.001). Moreover, for each 5 μmol/L homocysteine increment, the pooled RR was 1.52 (95% CI 1.26–1.84; P<0.001) for CHD mortality, 1.32 (95% CI 1.08–1.61; P=0.006) for cardiovascular mortality, and 1.27 (95% CI 1.03–1.55; P=0.023) for all-cause mortality.Elevated homocysteine levels are an independent predictor for subsequent cardiovascular mortality or all-cause mortality, and the risks were more pronounced among elderly persons.探讨普通人群血浆同型半胱氨酸水平升高是否能独立预测死亡风险。通过汇总12篇前瞻性研究, 定量分析血浆同型半胱氨酸水平升高与心血管疾病及各种死亡风险因子的关系。通过检索PubMed和Embase数据库, 收集普通人群中血浆同型半胱氨酸水平与死亡关系的前瞻性观察性研究, 采用STATA统计软件进行meta分析。血浆同型半胱氨酸水平升高是心血管疾病及各种原因死亡风险增加的一个独立预测因素, 在老年人群中尤为明显。 |
| Starting Page | 78 |
| Ending Page | 86 |
| Page Count | 9 |
| File Format | |
| ISSN | 16731581 |
| Journal | Journal of Zhejiang University SCIENCE B |
| Volume Number | 16 |
| Issue Number | 1 |
| e-ISSN | 18621783 |
| Language | Chinese |
| Publisher | Zhejiang University Press |
| Publisher Date | 2015-01-11 |
| Publisher Place | Hangzhou |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Homocysteine Coronary heart disease Cardiovascular mortality All-cause mortality Meta-analysis Biomedicine |
| Content Type | Text |
| Resource Type | Article |
| Subject | Veterinary Medicine Biochemistry, Genetics and Molecular Biology Pharmacology, Toxicology and Pharmaceutics |
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