| Content Provider |
World Health Organization (WHO)-Global Index Medicus |
| Author |
Kweon, Sun-Seog Shu, Xiao-Ou Xiang, Yongbing Yang, Gong Ji, Bu-Tian Li, Honglan Gao, Yu-Tang Zheng, Wei Shrubsole, Martha J. |
| Description |
Country affiliation: South Korea Author Affiliation: Kweon SS ( Authors' Affiliations: Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee); Shu XO ( Authors' Affiliations: Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee); Xiang Y ( Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China); Yang G ( Authors' Affiliations: Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee); Ji BT ( Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland); Li H ( Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China); Gao YT ( Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China); Zheng W ( Authors' Affiliations: Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee); Shrubsole MJ ( Authors' Affiliations: Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee) |
| Abstract |
BACKGROUND: Previous studies on the association between one-carbon dietary factors and gastric cancer risk have been inconsistent. METHODS: We investigated this association using data from a prospective study, the Shanghai Women's Health Study (1997-2010), including 323 distal gastric cancer cases identified from 73,009 Chinese women. HRs and 95% confidence intervals (CI) were estimated using Cox proportional hazard regression after adjusting for confounders. RESULTS: Overall, no statistically significant association of gastric cancer was observed with dietary intake of folate, methionine, or B vitamins. However, when stratified by menopausal status, higher intake of riboflavin was associated with decreased gastric cancer risk in premenopausal women with HR of 0.35 (95% CI, 0.17-0.73), 0.48 (0.24-0.97), 0.28 (0.12-0.65), and 0.23 (0.07-0.91), respectively, for the quintiles 2 to 5 intake groups compared with the lowest quintile intake (P for trend = 0.02). Among premenopausal women, highest intake of folate was associated with increased gastric cancer risk (HR, 2.62; 95% CI, 1.04-6.59). There were no statistically significant associations observed among postmenopausal women. CONCLUSIONS: These results suggest that dietary factors involved in one-carbon metabolism are associated with gastric cancer risk among premenopausal women. IMPACT: Riboflavin may be a protective factor and folate may be a risk factor for premenopausal gastric cancer. |
| File Format |
HTM / HTML |
| ISSN |
10559965 |
| e-ISSN |
15387755 |
| DOI |
10.1158/1055-9965.EPI-14-0038 |
| Journal |
Cancer Epidemiology Biomarkers & Prevention |
| Issue Number |
7 |
| Volume Number |
23 |
| Language |
English |
| Publisher |
American Association for Cancer Research |
| Publisher Date |
2014-07-01 |
| Publisher Place |
United States |
| Access Restriction |
Open |
| Subject Keyword |
Discipline Cancer epidemiology Diet Folic Acid Methionine Stomach Neoplasms Epidemiology Vitamin B Complex Asian Continental Ancestry Group Diet Surveys Research Support, N.i.h., Extramural |
| Content Type |
Text |
| Resource Type |
Article |
| Subject |
Epidemiology Oncology |
