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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Templeton, Arnoud J. Ace, Olga McNamara, Mairéad G. Al-Mubarak, Mustafa Vera-Badillo, Francisco E. Hermanns, Thomas Seruga, Bostjan Ocaña, Alberto Tannock, Ian F. Amir, Eitan |
| Description | Author Affiliation: Templeton AJ ( Authors' Affiliations: Division of Medical Oncology and Hematology, Department of Medicine); Ace O ( Authors' Affiliations: Division of Medical Oncology and Hematology, Department of Medicine); McNamara MG ( Authors' Affiliations: Division of Medical Oncology and Hematology, Department of Medicine); Al-Mubarak M ( Authors' Affiliations: Division of Medical Oncology and Hematology, Department of Medicine); Vera-Badillo FE ( Authors' Affiliations: Division of Medical Oncology and Hematology, Department of Medicine); Hermanns T ( Department of Surgical Oncology, Department of Surgery, Princess Margaret Cancer Centre, University of Toronto, Toronto, Canada); Seruga B ( Department of Medical Oncology, Institute of Oncology Ljubljana, Slovenia); Ocaña A ( Translational Oncology Unit, University Hospital, Albacete, Spain.); Tannock IF ( Authors' Affiliations: Division of Medical Oncology and Hematology, Department of Medicine); Amir E ( Authors' Affiliations: Division of Medical Oncology and Hematology, Department of Medicine) |
| Abstract | BACKGROUND: Inflammation influences cancer development and progression. An elevated platelet to lymphocyte ratio (PLR), a marker of inflammation, has been linked to poor prognosis in several malignancies. Here, we quantify the prognostic impact of this biomarker. METHODS: A systematic review of databases was conducted to identify publications exploring the association of blood PLR and overall survival (OS) in solid tumors. Data were pooled in a meta-analysis. Pooled HRs for OS by disease group and by PLR cutoff groups were computed and weighted using generic inverse-variance and random-effect modeling. RESULTS: Twenty studies comprising 12,754 patients were assessed. Cutoffs for PLR defining risk groups ranged from 150 to 300 and were dichotomous (12 studies; group 1) or split into three groups (<150/150-300/>300, 8 studies; group 2). Higher PLR was associated with significantly worse OS in group 1 [HR = 1.87; 95% confidence interval (CI, 1.49-2.34); P < 0.001] and with a nonsignificant association in group 2 (HR per higher category = 1.21; 95%CI, 0.97-1.50; P = 0.10). The size of effect of PLR on OS was greater for metastatic disease (HR[group 1] = 2.0; 95% CI, 1.6-2.7; HR[group 2] = 1.6; 95% CI, 1.1-2.4) than for early-stage disease (HR[group 1] = 1.5; 95% CI, 1.0-2.2; HR[group 2] = 1.0; 95% CI, 0.8-1.3). A significant association was observed for colorectal, hepatocellular, gastroesophageal, ovarian, and pancreatic carcinoma in group 1 and for colorectal cancers in group 2. CONCLUSION: A high PLR is associated with worse OS in various solid tumors. Further research of its regulation and relevance in daily practice is warranted. IMPACT: PLR is a readily available and inexpensive biomarker with independent prognostic value in solid tumors. |
| File Format | HTM / HTML |
| ISSN | 10559965 |
| e-ISSN | 15387755 |
| Journal | Cancer Epidemiology Biomarkers & Prevention |
| Issue Number | 7 |
| Volume Number | 23 |
| Language | English |
| Publisher | American Association for Cancer Research |
| Publisher Date | 2014-07-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Discipline Cancer epidemiology Lymphocyte Count Neoplasms Blood Mortality Platelet Count Prognosis Meta-analysis Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Epidemiology Oncology |
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