NDLI: Clopidogrel Resistance in Neurovascular Stenting: Correlations between Light Transmission Aggregometry, VerifyNow, and the Multiplate.

Please wait, while we are loading the content...

Dynamic Angiography and Perfusion Imaging Using Flat Detector CT in the Angiography Suite: A Pilot Study in Patients with Acute Middle Cerebral Artery Occlusions.

Cognitive and White Matter Tract Differences in MS and Diffuse Neuropsychiatric Systemic Lupus Erythematosus.

Hemodynamic Differences in Intracranial Aneurysms before and after Rupture.

A Comparison of 4D DSA with 2D and 3D DSA in the Analysis of Normal Vascular Structures in a Canine Model.

Combined Use of Mechanical Thrombectomy with Angioplasty and Stenting for Acute Basilar Occlusions with Underlying Severe Intracranial Vertebrobasilar Stenosis: Preliminary Experience from a Single Chinese Center.

Timing-Invariant CT Angiography Derived from CT Perfusion Imaging in Acute Stroke: A Diagnostic Performance Study.

MRI Tractography of Corticospinal Tract and Arcuate Fasciculus in High-Grade Gliomas Performed by Constrained Spherical Deconvolution: Qualitative and Quantitative Analysis.

Cytotoxic Edema in Posterior Reversible Encephalopathy Syndrome: Correlation of MRI Features with Serum Albumin Levels.

Single-Layer WEBs: Intrasaccular Flow Disrupters for Aneurysm TreatmentFeasibility Results from a European Study.

Subspecialty Virtual Impact Factors within a Dedicated Neuroimaging Journal.

Significance of Development and Reversion of Collaterals on MRI in Early Neurologic Improvement and Long-Term Functional Outcome after Intravenous Thrombolysis for Ischemic Stroke.

Additional Value of Intra-Aneurysmal Hemodynamics in Discriminating Ruptured versus Unruptured Intracranial Aneurysms.

Progressive versus Nonprogressive Intracranial Dural Arteriovenous Fistulas: Characteristics and Outcomes.

Diagnostic Accuracy of 4 Commercially Available Semiautomatic Packages for Carotid Artery Stenosis Measurement on CTA.

Meta-Analysis of CSF Diversion Procedures and Dural Venous Sinus Stenting in the Setting of Medically Refractory Idiopathic Intracranial Hypertension.

Accuracy of Parenchymal Cerebral Blood Flow Measurements Using Pseudocontinuous Arterial Spin-Labeling in Healthy Volunteers.

Differentiation between Cystic Pituitary Adenomas and Rathke Cleft Cysts: A Diagnostic Model Using MRI.

Improved Image Quality in Head and Neck CT Using a 3D Iterative Approach to Reduce Metal Artifact.

Clopidogrel Resistance in Neurovascular Stenting: Correlations between Light Transmission Aggregometry, VerifyNow, and the Multiplate.

Seizure Frequency Can Alter Brain Connectivity: Evidence from Resting-State fMRI.

Hyperintense Dentate Nuclei on T1-Weighted MRI: Relation to Repeat Gadolinium Administration.

Independent Poor Prognostic Factors for True Progression after Radiation Therapy and Concomitant Temozolomide in Patients with Glioblastoma: Subependymal Enhancement and Low ADC Value.

Changing Clinical and Therapeutic Trends in Tentorial Dural Arteriovenous Fistulas: A Systematic Review.

ERRATUM.

Gray Matter Volume Reduction Is Associated with Cognitive Impairment in Neuromyelitis Optica.

We Are Not Alone.

Standardized Brain Tumor Imaging Protocol for Clinical Trials.

Year: 2015 Volume: 36 Issue: 9

Year: 2015 Volume: 36 Issue: 8

Year: 2015 Volume: 36 Issue: 7

Year: 2015 Volume: 36 Issue: 6

Year: 2015 Volume: 36 Issue: 5

Year: 2015 Volume: 36 Issue: 4

Year: 2015 Volume: 36 Issue: 3

Year: 2015 Volume: 36 Issue: 2

Year: 2015 Volume: 36 Issue: 1

Year: 2014 Volume: 35

Year: 2013 Volume: 34

Year: 2012 Volume: 33

Year: 2011 Volume: 32

Year: 2010 Volume: 31

Year: 2009 Volume: 30

Year: 2008 Volume: 29

Clopidogrel Resistance in Neurovascular Stenting: Correlations between Light Transmission Aggregometry, VerifyNow, and the Multiplate.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Flechtenmacher, N. Kämmerer, F. Dittmer, R. Budde, U. Michels, P. Röther, J. Eckert, B.
Description	Author Affiliation: Flechtenmacher N ( From the Departments of Neuroradiology (N.F., F.K., B.E.).); Kämmerer F ( From the Departments of Neuroradiology (N.F., F.K., B.E.).); Dittmer R ( Department of Laboratory Medicine (R.D., U.B.), Medilys Laboratory Company, Hamburg, Germany.); Budde U ( Department of Laboratory Medicine (R.D., U.B.), Medilys Laboratory Company, Hamburg, Germany.); Michels P ( Neurology (P.M., J.R.), Asklepios Klinik Altona, Hamburg, Germany.); Röther J ( Neurology (P.M., J.R.), Asklepios Klinik Altona, Hamburg, Germany.); Eckert B ( From the Departments of Neuroradiology (N.F., F.K., B.E.) b.eckert@asklpios.com.)
Abstract	BACKGROUND AND PURPOSE: Clopidogrel resistance is blamed for thromboembolic complications in neurovascular stent placement. Platelet-function assays are weakly standardized. The aim of this study was to correlate the results of 3 different platelet-inhibition measurements (from light transmission aggregometry, the VerifyNow P2Y12 test, and the Multiplate analyzer) and their relation to periprocedural thromboembolic complications in elective neurovascular stent placement. MATERIALS AND METHODS: Clopidogrel resistance was determined on the day of the intervention according to predefined platelet reactivity cutoff values. All 3 tests were performed in 103 consecutive neurovascular stent-placement procedures in 97 patients (extracranial, n = 77; intracranial, n = 26). RESULTS: The clopidogrel resistance rates were 47.6% (light transmission aggregometry), 50.5% (VerifyNow), and 35.9% (Multiplate). In 67% of the patients, clopidogrel resistance was present according to at least one method. The correlations of qualitative results that classified a patient as responsive or resistant to clopidogrel were 67.9% for light transmission aggregometry with VerifyNow, 77.7% for light transmission aggregometry with the Multiplate, and 66% for VerifyNow with the Multiplate. Periprocedural thromboembolic complications (n = 9) occurred more frequently in patients who were determined by all 3 methods to be clopidogrel resistant. The difference was most pronounced with light transmission aggregometry (complication rates, 14.4% [clopidogrel-resistant patients] vs 3.7% [clopidogrel-responsive patients]). Sensitivity and specificity rates of clopidogrel resistance in relation to embolic complications were, respectively, 78% and 55% for light transmission aggregometry, 67% and 51% for VerifyNow, and 44% and 67% for the Multiplate. CONCLUSIONS: Clopidogrel resistance is a frequent finding in patients who undergo neurovascular stent placement. The correlations among the different testing methods are only modest and differ considerably. Light transmission aggregometry results seem to correlate with thromboembolic complications more accurately than with VerifyNow and Multiplate point-of-care methods.
File Format	HTM / HTML
ISSN	01956108
e-ISSN	1936959X
Journal	American Journal of Neuroradiology
Issue Number	10
Volume Number	36
Language	English
Publisher	American Journal of Neuroradiology
Publisher Date	2015-10-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Neurology Discipline Radiology Brain Ischemia Therapy Drug Resistance Embolization, Therapeutic Intracranial Aneurysm Intracranial Embolism Prevention & Control Platelet Aggregation Inhibitors Adverse Effects Therapeutic Use Platelet Aggregation Drug Effects Platelet Function Tests Instrumentation Stents Ticlopidine Analogs & Derivatives Point-of-care Systems Statistics As Topic Comparative Study
Content Type	Text
Resource Type	Article
Subject	Radiology, Nuclear Medicine and Imaging Neurology (clinical)

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Clopidogrel resistance is associated with thromboembolic complications in patients undergoing neurovascular stenting.

Thromboembolic complications in patients with clopidogrel resistance after coil embolization for unruptured intracranial aneurysms.

Preinterventional clopidogrel response variability for coil embolization of intracranial aneurysms: clinical implications.

Platelet aggregation in intracranial stents may mimic in-stent restenosis.

Incidence of cerebral ischemic events after discontinuation of clopidogrel in patients with intracranial aneurysms treated with stent-assisted techniques.

Monitoring of clopidogrel-related platelet inhibition: correlation of nonresponse with clinical outcome in supra-aortic stenting.

Precision of VerifyNow P2Y12 Assessment of Clopidogrel Response in Patients Undergoing Cerebral Aneurysm Flow Diversion.

Triple antiplatelet therapy with addition of cilostazol to aspirin and clopidogrel for Y-stent-assisted coil embolization of cerebral aneurysms.

Short bowel syndrome and clopidogrel non-responsiveness: a new indication for platelet aggregometry?

Clopidogrel Resistance in Neurovascular Stenting: Correlations between Light Transmission Aggregometry, VerifyNow, and the Multiplate.

Similar Documents

Clopidogrel resistance is associated with thromboembolic complications in patients undergoing neurovascular stenting.

Thromboembolic complications in patients with clopidogrel resistance after coil embolization for unruptured intracranial aneurysms.

Preinterventional clopidogrel response variability for coil embolization of intracranial aneurysms: clinical implications.

Platelet aggregation in intracranial stents may mimic in-stent restenosis.

Incidence of cerebral ischemic events after discontinuation of clopidogrel in patients with intracranial aneurysms treated with stent-assisted techniques.

Monitoring of clopidogrel-related platelet inhibition: correlation of nonresponse with clinical outcome in supra-aortic stenting.

Precision of VerifyNow P2Y12 Assessment of Clopidogrel Response in Patients Undergoing Cerebral Aneurysm Flow Diversion.

Triple antiplatelet therapy with addition of cilostazol to aspirin and clopidogrel for Y-stent-assisted coil embolization of cerebral aneurysms.

Short bowel syndrome and clopidogrel non-responsiveness: a new indication for platelet aggregometry?

Clopidogrel Resistance in Neurovascular Stenting: Correlations between Light Transmission Aggregometry, VerifyNow, and the Multiplate.