NDLI: Accuracy of Parenchymal Cerebral Blood Flow Measurements Using Pseudocontinuous Arterial Spin-Labeling in Healthy Volunteers.

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Accuracy of Parenchymal Cerebral Blood Flow Measurements Using Pseudocontinuous Arterial Spin-Labeling in Healthy Volunteers.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Ambarki, K. Wåhlin, A. Zarrinkoob, L. Wirestam, R. Petr, J. Malm, J. Eklund, A.
Description	Author Affiliation: Ambarki K ( From the Department of Radiation Sciences (K.A., A.W., A.E.) Centre for Biomedical Engineering and Physics (K.A., A.E.) khalid.ambarki@vll.se.); Wåhlin A ( From the Department of Radiation Sciences (K.A., A.W., A.E.) Center for Functional Brain Imaging (A.W., A.E.).); Zarrinkoob L ( Department of Clinical Neuroscience (L.Z., J.M.), Umeå University, Umeå, Sweden.); Wirestam R ( Department of Medical Radiation Physics (R.W.), Lund University, Lund, Sweden.); Petr J ( PET Center (J.P.), Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany.); Malm J ( Department of Clinical Neuroscience (L.Z., J.M.), Umeå University, Umeå, Sweden.); Eklund A ( From the Department of Radiation Sciences (K.A., A.W., A.E.) Centre for Biomedical Engineering and Physics (K.A., A.E.) Center for Functional Brain Imaging (A.W., A.E.).)
Abstract	BACKGROUND AND PURPOSE: The arterial spin-labeling method for CBF assessment is widely available, but its accuracy is not fully established. We investigated the accuracy of a whole-brain arterial spin-labeling technique for assessing the mean parenchymal CBF and the effect of aging in healthy volunteers. Phase-contrast MR imaging was used as the reference method. MATERIALS AND METHODS: Ninety-two healthy volunteers were included: 49 young (age range, 20-30 years) and 43 elderly (age range, 65-80 years). Arterial spin-labeling parenchymal CBF values were averaged over the whole brain to quantify the mean pCBF(ASL) value. Total CBF was assessed with phase-contrast MR imaging as the sum of flows in the internal carotid and vertebral arteries, and subsequent division by brain volume returned the pCBF(PCMRI) value. Accuracy was considered as good as that of the reference method if the systematic difference was less than 5 mL/min/100 g of brain tissue and if the 95% confidence intervals were equal to or better than ±10 mL/min/100 g. RESULTS: pCBF(ASL) correlated to pCBF(PCMRI) (r = 0.73; P < .001). Significant differences were observed between the pCBF(ASL) and pCBF(PCMRI) values in the young (P = .001) and the elderly (P < .001) volunteers. The systematic differences (mean ± 2 standard deviations) were -4 ± 14 mL/min/100 g in the young subjects and 6 ± 12 mL/min/100 g in the elderly subjects. Young subjects showed higher values than the elderly subjects for pCBF(PCMRI) (young, 57 ± 8 mL/min/100 g; elderly, 54 ± 7 mL/min/100 g; P = .05) and pCBF(ASL) (young, 61 ± 10 mL/min/100 g; elderly, 48 ± 10 mL/min/100 g; P < .001). CONCLUSIONS: The limits of agreement were too wide for the arterial spin-labeling method to be considered satisfactorily accurate, whereas the systematic overestimation in the young subjects and underestimation in the elderly subjects were close to acceptable. The age-related decrease in parenchymal CBF was augmented in arterial spin-labeling compared with phase-contrast MR imaging.
File Format	HTM / HTML
ISSN	01956108
e-ISSN	1936959X
Journal	American Journal of Neuroradiology
Issue Number	10
Volume Number	36
Language	English
Publisher	American Journal of Neuroradiology
Publisher Date	2015-10-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Neurology Discipline Radiology Brain Blood Supply Cerebrovascular Circulation Physiology Electron Spin Resonance Spectroscopy Spin Labels Aging Healthy Volunteers Magnetic Resonance Imaging Sensitivity And Specificity Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Radiology, Nuclear Medicine and Imaging Neurology (clinical)

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