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Efficacy of daily intake of Lactobacillus casei Shirota on respiratory symptoms and influenza vaccination immune response: a randomized, double-blind, placebo-controlled trial in healthy elderly nursing home residents.

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Efficacy of daily intake of Lactobacillus casei Shirota on respiratory symptoms and influenza vaccination immune response: a randomized, double-blind, placebo-controlled trial in healthy elderly nursing home residents.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Van Puyenbroeck, Karolien Hens, Niel Coenen, Samuel Michiels, Barbara Beunckens, Caroline Molenberghs, Geert Van Royen, Paul Verhoeven, Veronique
Spatial Coverage	Belgium
Description	Country affiliation: Belgium Author Affiliation: Van Puyenbroeck K ( Department of Primary and Interdisciplinary Care, University of Antwerp, Antwerp, Belgium. karolien.vanpuyenbroeck@ua.ac.be)
Abstract	BACKGROUND: Age is associated with immune dysregulation, which results in an increased infection rate and reduced effectiveness of vaccination. OBJECTIVE: We assessed whether an intervention with Lactobacillus casei Shirota (LcS) in elderly nursing home residents reduced their susceptibility to respiratory symptoms and improved their immune response to influenza vaccination. DESIGN: Between October 2007 and April 2008, a randomized, double-blind, placebo-controlled trial was conducted in 737 healthy people aged ≥ 65 y in 53 nursing homes in Antwerp, Belgium. Volunteers were randomly assigned to receive a probiotic (n = 375; 2 bottles of fermented milk that contained ≥ 6.5 × 10(9) live LcS/bottle) or a placebo (n = 362; similar drink with no bacteria) for 176 d. After 21 d, all subjects received an influenza vaccination. Primary outcome parameters were the number of days with respiratory symptoms, the probability of respiratory symptoms, and antiinfluenza antibody titer by hemagglutination inhibition after vaccination. RESULTS: Univariate and multivariate modeling showed no effect of the probiotic on clinical outcome parameters. Generalized linear mixed modeling showed no effect of the probiotic itself on the probability of respiratory symptoms [OR of probiotic: 0.8715; 95% CI: 0.6168, 1.2887). No significant difference regarding the influenza-vaccination immune response was shown. CONCLUSION: The results of this study show that daily consumption of a fermented milk drink that contains LcS has no statistically or clinically significant effect on the protection against respiratory symptoms. This trial was registered at clinicaltrials.gov as NCT00849277.
File Format	HTM / HTML
ISSN	00029165
e-ISSN	19383207
Journal	American Journal of Clinical Nutrition
Issue Number	5
Volume Number	95
Language	English
Publisher	American Society for Nutrition
Publisher Date	2012-05-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Nutritional Sciences Influenza Vaccines Immunology Lactobacillus Casei Microbiology Probiotics Administration & Dosage Animals Antibodies Blood Belgium Double-blind Method Fermentation Hemagglutination Inhibition Tests Logistic Models Multivariate Analysis Nursing Homes Vaccination Multicenter Study Randomized Controlled Trial Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Nutrition and Dietetics Medicine

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Efficacy of daily intake of Lactobacillus casei Shirota on respiratory symptoms and influenza vaccination immune response: a randomized, double-blind, placebo-controlled trial in healthy elderly nursing home residents.