NDLI: Prognostic significance of ATM and cyclin B1 in pancreatic neuroendocrine tumor

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Shin, Jae Uk Lee, Chang Hoon Lee, Kyu Taek Lee, Jong Kyun Lee, Kwang Hyuck Kim, Kwang Min Kim, Kyoung-Mee Park, Sang-Mo Rhee, Jong Chul
Description	Country affiliation: South Korea Author Affiliation: Shin JU ( Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.)
Abstract	Ataxia telangiectasia mutated kinase (ATM) and cyclin B1 are involved in cell cycle control. The prognostic significance of both molecules has not yet been investigated in pancreatic neuroendocrine tumors. The aim of this study was to evaluate the clinical and prognostic significance of ATM and cyclin B1 in patients with pancreatic neuroendocrine tumors. A total of 107 pancreatic neuroendocrine tumor specimens that were surgically resected were immunohistochemically investigated using the tissue microarray technique. Clinicopathologic results and survival were evaluated retrospectively. High expression of ATM and cyclin B1 was related to well-differentiated endocrine tumors of the World Health Organization (WHO) classification, but not related to TNM stages. The high ATM expression group (ATM ≥ 4) had a significantly smaller tumor size, lower recurrence rate, more number of functioning tumor, and well differentiation of WHO classification. The high cyclin B1 expression group (cyclin B1 ≥5) was related to smaller tumor size, less vascular invasion, less recurrence rate, and less death rate. However, cyclin B1 was the only significant factor for survival following multivariate analysis (p = 0.008; OR, 0.54; 95 % CI, 0.35–0.85). The current results suggested that expression of ATM and cyclin B1 may be useful markers to identify patients with poor prognosis who may benefit from close follow-up and aggressive therapy in pancreatic neuroendocrine tumors.
File Format	HTM / HTML
ISSN	10104283
Issue Number	5
Volume Number	33
e-ISSN	14230380
Journal	Tumor Biology
Language	English
Publisher	Springer
Publisher Date	2012-10-01
Publisher Place	Netherlands
Access Restriction	Subscribed
Subject Keyword	Discipline Medicine__semicolon__oncology Cell Cycle Proteins Metabolism Cyclin B1 Dna-binding Proteins Neuroendocrine Tumors Pathology Pancreatic Neoplasms Protein-serine-threonine Kinases Tumor Suppressor Proteins Adult Aged Ataxia Telangiectasia Mutated Proteins Tumor Markers, Biological Female Humans Male Middle Aged Neoplasm Staging Mortality Prognosis Journal Article
Content Type	Text
Resource Type	Article
Subject	Medicine Cancer Research

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