NDLI: Nuclear p63 expression in osteoblastic tumors.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Kallen, Michael E. Sanders, Melinda E. Gonzalez, Adriana L. Black, Jennifer O. Keedy, Vicki L. Hande, Kenneth R. Homlar, Kelly C. Halpern, Jennifer L. Holt, Ginger E. Schwartz, Herbert S. Coffin, Cheryl M. Cates, Justin M. M.
Description	Country affiliation: United States Author Affiliation: Kallen ME ( Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Medical Center North, C-3322, 1161 21st Ave. South, Nashville, TN 37232, USA.)
Abstract	Expression of the p63 tumor suppressor protein has been reported in the mononuclear stromal cells of giant cell tumor of the bone, which may represent osteoblast-precursor cells. Only a limited number of osteoblastic tumors have been studied for p63 expression thus far. We therefore examined whether p63 may serve as a marker for osteoblastic differentiation in osteosarcomas or as a differential diagnostic marker to distinguish osteoblastoma from osteosarcoma. Immunohistochemical stains for p63 were performed on a tissue microarray containing 71 chemotherapy naïve biopsy samples of osteosarcoma, 21 whole sections of osteosarcoma, and 8 osteoblastomas. Nuclear p63 was detected in seven of eight osteoblastomas but was restricted to stromal cells within primitive, immature-appearing areas of osteoid deposition. Although only 7 of 71 (10 %) biopsy samples of osteosarcoma represented on the tissue microarray were positive for p63, 7 of 21 (33 %) osteosarcomas were positive when whole tissue sections were evaluated. Although p63 is detected in most osteoblastomas, it is also observed in a significant subset of osteosarcomas, severely limiting its utility in distinguishing between benign and malignant osteoblastic tumors. The relatively low prevalence of p63 expression in osteosarcoma would also seem to preclude its use as a marker of osteoblastic differentiation in skeletal sarcomas.
File Format	HTM / HTML
ISSN	10104283
Issue Number	5
Volume Number	33
e-ISSN	14230380
Journal	Tumor Biology
Language	English
Publisher	Springer
Publisher Date	2012-10-01
Publisher Place	Netherlands
Access Restriction	Subscribed
Subject Keyword	Discipline Medicine__semicolon__oncology Bone Neoplasms Metabolism Osteoblastoma Osteosarcoma Transcription Factors Tumor Suppressor Proteins Adolescent Adult Tumor Markers, Biological Genetics Child Female Humans Male Middle Aged Young Adult Journal Article Research Support, N.i.h., Extramural
Content Type	Text
Resource Type	Article
Subject	Medicine Cancer Research

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