NDLI: Investigation of microRNA-155 as a serum diagnostic and prognostic biomarker for colorectal cancer.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Lv, Zhong-chuan Fan, Yong-sheng Chen, Hong-bing Zhao, Da-wei
Description	Author Affiliation: Lv ZC ( Department of Gastrointestinal Surgery, Yantai Yuhuangding Hospital, Yantai, 264000, Shandong, China, dr_lvzhongchuan@126.com.)
Abstract	The aim of the present study was to explore serum microRNA-155 (miR-155) expression in patients with colorectal cancer (CRC) and examined the potential usefulness of this molecule as a biomarker for diagnosis and prognosis in CRC. Serum samples were obtained between May 2007 and March 2013 from 146 CRC patients and 60 healthy controls. Serum miR-155 expression levels were measured by quantitative real time reverse transcription-polymerase chain reaction (qRT-PCR). Survival curves were obtained using the Kaplan-Meier method and assessed by the log-rank test. The receiver operating characteristic (ROC) curve was used for the prediction of cut-off values of the markers. Serum miR-155 expression level on average was upregulated in CRC patients compared with the matched healthy controls (P < 0.001). ROC curve analysis showed that miR-155 was a useful marker for discriminating cases from healthy controls, with an area under the ROC curve (AUC) of 0.776 (95% confidence interval (CI) 0.714 to 0.837, P < 0.001). Kaplan-Meier analysis with the log-rank test indicated that high serum miR-155 expression had a significant impact on overall survival (38.2 vs. 69.9%; P < 0.001) and progression-free survival (34.8 vs. 66.0%; P < 0.001). In conclusion, the detection of miR-155 levels in the serum might serve as a new tumor biomarker in the diagnosis and assessment of prognosis of CRC.
File Format	HTM / HTML
ISSN	10104283
Issue Number	3
Volume Number	36
e-ISSN	14230380
Journal	Tumor Biology
Language	English
Publisher	Springer
Publisher Date	2015-03-01
Publisher Place	Netherlands
Access Restriction	Subscribed
Subject Keyword	Discipline Medicine__semicolon__oncology Tumor Markers, Biological Blood Colorectal Neoplasms Genetics Micrornas Adult Aged Aged, 80 And Over Diagnosis Pathology Disease-free Survival Female Gene Expression Regulation, Neoplastic Humans Kaplan-meier Estimate Lymphatic Metastasis Male Middle Aged Neoplasm Staging Prognosis Roc Curve Journal Article
Content Type	Text
Resource Type	Article
Subject	Medicine Cancer Research

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