NDLI: The prognostic role of baseline CEA and CA 19-9 values and their time-dependent variations in advanced colorectal cancer patients submitted to first-line therapy.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Tampellini, M. Ottone, A. Alabiso, I. Baratelli, C. Forti, L. Berruti, A. Aroasio, E. Scagliotti, G. V.
Description	Country affiliation: Italy Author Affiliation: Tampellini M ( SCDU Oncologia, AOU San Luigi Gonzaga, Orbassano, Italy.)
Abstract	Serum marker evaluation is an easily available prognostic indicator that may help clinicians to discriminate patients with an aggressive disease; there are few and small-sized studies exploring the prognostic role of baseline carcinoembryonic antigen (CEA) values and their variations during first-line therapy, and even fewer data are available for carbohydrate antigen 19-9 (CA 19-9). Our aim was to analyze the role of those prognostic markers to exploit them in daily clinical practice. Data of 892 patients with marker determination before and 3 and/or 6 months during therapy were extracted from two institutional databases. Patients were grouped according to single marker variation as always negative (G0), decreasing (G1), stable (G2), or increasing (G3). We evaluated the progression-free survival (PFS) and the overall survival (OS) of all the patents and correlated them with CEA and CA 19-9 values. A concordance between response to therapy and marker decrease was evident in 50.2% and in 34.4% of the patients for CEA and CA 19-9. Patients with low CEA or CA 19-9 baseline values had a longer PFS (15.1 vs. 10.5; 13.6 vs. 10.2 months) and OS (32.0 vs. 22.3; 30.5 vs. 20.1 months). The same results of PFS and OS were obtained by analyzing the data of the four different groups. Multivariate analyses confirmed the independent prognostic role of CEA and CA 19-9. Baseline CEA and CA 19-9 levels and their kinetics demonstrated to be independent prognostic factors. CA 19-9 dosage is not recommended; a possible role of CA 19-9 in patients with negative CEA could be worth further evaluation.
File Format	HTM / HTML
ISSN	10104283
Issue Number	3
Volume Number	36
e-ISSN	14230380
Journal	Tumor Biology
Language	English
Publisher	Springer
Publisher Date	2015-03-01
Publisher Place	Netherlands
Access Restriction	Subscribed
Subject Keyword	Discipline Medicine__semicolon__oncology Ca-19-9 Antigen Metabolism Carcinoembryonic Antigen Colorectal Neoplasms Diagnosis Adult Aged Aged, 80 And Over Antineoplastic Agents Therapeutic Use Tumor Markers, Biological Drug Therapy Disease-free Survival Female Humans Male Middle Aged Prognosis Journal Article
Content Type	Text
Resource Type	Article
Subject	Medicine Cancer Research

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