NDLI: Alisertib (MLN8237), a selective Aurora-A kinase inhibitor, induces apoptosis in human tongue squamous cell carcinoma cell both in vitro and in vivo.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Qi, Lin Zhang, Yang
Description	Author Affiliation: Qi L ( Department of Orthodontics, School of Stomatology, China Medical University)
Abstract	Aurora-A kinases are overexpressed in many cancer tissues and cells. Alisertib is an investigational, orally administered, selective, small-molecule Aurora-A kinase inhibitor with preclinical activity against a broad range of tumors. Our study was aimed to detect the effects of alisertib on human tongue squamous cell carcinoma (HTSCC). Treatment of a human tongue squamous cell carcinoma cell line, HSC-3, with alisertib to inhibition of Aurora-A kinases reduced proliferation and induced apoptosis, which was accompanied by activation of the ATM/Chk2/p53 pathway. In vivo, inhibition of Aurora-A kinases in established xenografted tumors decreased tumor size and weight. Kaplan-Meyer survival analysis demonstrated that the cumulative survival time of mice without Aurora-A kinases was significantly longer than those with Aurora-A kinases. Our data provide the basis for developing alisertib to treat human tongue squamous cell carcinoma.
File Format	HTM / HTML
ISSN	10104283
Issue Number	3
Volume Number	36
e-ISSN	14230380
Journal	Tumor Biology
Language	English
Publisher	Springer
Publisher Date	2015-03-01
Publisher Place	Netherlands
Access Restriction	Subscribed
Subject Keyword	Discipline Medicine__semicolon__oncology Apoptosis Drug Effects Aurora Kinase A Antagonists & Inhibitors Azepines Pharmacology Carcinoma, Squamous Cell Drug Therapy Protein Kinase Inhibitors Pyrimidines Tongue Neoplasms Animals Ataxia Telangiectasia Mutated Proteins Metabolism Cell Line, Tumor Checkpoint Kinase 2 Humans Mice Mice, Nude Signal Transduction Tumor Suppressor Protein P53 Xenograft Model Antitumor Assays Methods Journal Article
Content Type	Text
Resource Type	Article
Subject	Medicine Cancer Research

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