NDLI: Effect of expressions of tumor necrosis factor and interleukin 1B on peritoneal metastasis of gastric cancer.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Guo, Lin Ou, Jin-Lei Zhang, Tong Ma, Liang Qu, Long-Fei
Description	Author Affiliation: Guo L ( Department of Gastrointestinal and Nutriology Surgery, Shengjing Hospital of China Medical University, Sanhao Street No.36, Heping District, Shenyang, 110004, People's Republic of China. guolin698@126.com.); Ou JL ( Department of Gastrointestinal and Nutriology Surgery, Shengjing Hospital of China Medical University, Sanhao Street No.36, Heping District, Shenyang, 110004, People's Republic of China.); Zhang T ( Department of Gastrointestinal and Nutriology Surgery, Shengjing Hospital of China Medical University, Sanhao Street No.36, Heping District, Shenyang, 110004, People's Republic of China.); Ma L ( Department of Gastrointestinal and Nutriology Surgery, Shengjing Hospital of China Medical University, Sanhao Street No.36, Heping District, Shenyang, 110004, People's Republic of China.); Qu LF ( Department of Gastrointestinal and Nutriology Surgery, Shengjing Hospital of China Medical University, Sanhao Street No.36, Heping District, Shenyang, 110004, People's Republic of China.)
Abstract	Our study aimed to investigate effect of expressions of tumor necrosis factor (TNF- ) and interleukin 1B (IL-1B) on peritoneal metastasis of gastric cancer (GC). From June 2012 to June 2014, a total of 60 patients with advanced peritoneal metastasis from GC were collected from Department of Gastrointestinal and Nutriology Surgery at Shengjing Hospital of China Medical University. Furthermore, 60 GC patients without peritoneal metastasis were enrolled as controls. Immunohistochemistry was performed to test TNF- and IL-1B expression, and logistic regression analysis was employed for evaluating risk factors for peritoneal metastasis of GC. Our results showed that TNF- expression in metastatic group and non-metastatic group was significantly different (P = 0.043), but no significant difference was found in IL-1B expression between two groups (P = 0.261). In addition, TNF- expression in metastatic group and non-metastatic group was associated with tumor size, depth of invasion, the degree of differentiation (all P < 0.05). Logistic regression analysis indicated that tumor size, depth of invasion, the degree of differentiation and TNF- expression were risk factors for peritoneal metastasis of GC (all P < 0.05). Our study found that TNF- expression may play a vital role in peritoneal metastasis of GC, while IL-1B expression might not be correlated with peritoneal metastasis.
File Format	HTM / HTML
ISSN	10104283
Issue Number	11
Volume Number	36
e-ISSN	14230380
Journal	Tumor Biology
Language	English
Publisher	Springer
Publisher Date	2015-11-01
Publisher Place	Netherlands
Access Restriction	Subscribed
Subject Keyword	Discipline Medicine__semicolon__oncology Interleukin-1beta Biosynthesis Peritoneal Neoplasms Genetics Stomach Neoplasms Tumor Necrosis Factor-alpha Adult Aged Aged, 80 And Over Female Gene Expression Regulation, Neoplastic Humans Male Middle Aged Neoplasm Metastasis Pathology Secondary Prognosis Risk Factors Journal Article
Content Type	Text
Resource Type	Article
Subject	Medicine Cancer Research

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